Studies of Interactions of Valsartan, Glimepiride and Ciprofloxacin HCl by DSC and HPLC

Authors

  • Mohammad Farhadur Rahman Department of Chemistry, University of Dhaka, Dhaka-1000
  • Md Abdus Salam Department of Chemistry, University of Dhaka, Dhaka-1000
  • Asma Rahman Centre for Advanced Research in Sciences, University of Dhaka, Dhaka-1000
  • Md Zakir Sultan Centre for Advanced Research in Sciences, University of Dhaka, Dhaka-1000

DOI:

https://doi.org/10.3329/bpj.v20i2.37885

Keywords:

Drug-Drug Interaction, Glimepiride, Ciprofloxacin HCl, Valsartan, DSC, HPLC

Abstract

This article deals with the results of in vitro interactions among glimepiride, ciprofloxacin HCl and valsartan at the molar ratio of 1:1:1 by DSC and HPLC method. The DSC thermogram of the mixture (glimepiride, ciprofloxacin HCl and valsartan) showed different melting endotherm than the melting endotherm for standard valsartan, ciprofloxacin HCl and glimepiride. Since the melting endotherms of mixture and individual drugs were not identical, it demonstrated the presence of interactions among the drugs. This result was further verified by HPLC to observe their recovery range. The % recovery ranges were found as 25.33, 23.49 and 135.82% for glimepiride, ciprofloxacin HCl and valsartan, respectively. The abnormal percentage recovery range and peak areas fluctuation further indicated the interactions among glimepiride, ciprofloxacin HCl and valsartan.

Bangladesh Pharmaceutical Journal 20(2): 194-199, 2017

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Published

2018-08-14

How to Cite

Rahman, M. F., Salam, M. A., Rahman, A., & Sultan, M. Z. (2018). Studies of Interactions of Valsartan, Glimepiride and Ciprofloxacin HCl by DSC and HPLC. Bangladesh Pharmaceutical Journal, 20(2), 194–199. https://doi.org/10.3329/bpj.v20i2.37885

Issue

Vol. 20 No. 2 (2017)

Section

Articles