Evaluation of Analgesic, Antioxidant, Cytotoxic and Thrombolytic Potential of Stachytarpheta cayennensis (Rich.) Vahl Leaves

Authors

  • Asif Uj Jaman Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi, Dhaka-1205, Bangladesh
  • Sharmin Akhter Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi, Dhaka-1205, Bangladesh
  • Saimon Shahriar Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi, Dhaka-1205, Bangladesh
  • Md Bappy Hawlader Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi, Dhaka-1205, Bangladesh
  • Mehedi Islam Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi, Dhaka-1205, Bangladesh
  • Mohammad A Rashid Phytochemical Research Laboratory, Department of Pharmaceutical Chemistry Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh

DOI:

https://doi.org/10.3329/bpj.v26i1.64217

Keywords:

Stachytarpheta cayennensis, analgesic, thrombolytic, cytotoxic.

Abstract

The current study was undertaken for the preliminary investigation of the analgesic, cytotoxic, antioxidant, and thrombolytic properties of the methanolic extract of Stachytarpheta cayennensis (Rich.) Vahl leaves. Both the central and peripheral analgesic action of the crude extract of methanol were significant and the analgesic effect increases with the increasing of dose and time with the pronounced effect at 600 mg/kg body weight. According to the brine shrimp lethality bioassay, the pet-ether soluble fraction (PESF) displayed notable cytotoxic action showing LC50 value (5.33 μg/ml) among the fractions as compared to the standard vincristine sulfate (0.452 μg/ml) and crude extract of the leaves contained a total phenolic content ranging from 18.68-145.98 mg of GAE/gm while revealing moderate thrombolytic activity.

Bangladesh Pharmaceutical Journal 26(1): 45-50, 2023 (January)

Downloads

Download data is not yet available.
Abstract
2
PDF
3

Downloads

Published

2023-01-31

How to Cite

Jaman, A. U. ., Akhter, S. ., Shahriar, S. ., Hawlader, M. B., Islam, M. ., & Rashid, M. A. (2023). Evaluation of Analgesic, Antioxidant, Cytotoxic and Thrombolytic Potential of Stachytarpheta cayennensis (Rich.) Vahl Leaves. Bangladesh Pharmaceutical Journal, 26(1), 45–50. https://doi.org/10.3329/bpj.v26i1.64217

Issue

Section

Articles