In vitro Assessment of Antioxidant, Membrane Stabilization and Thrombolytic Activities of Ethanolic Extract of Lagenaria siceraria Fruit

Authors

  • Arifa Sultana Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Banglades
  • Abida Sultana Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Banglades
  • Fahima Aktar Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Banglades
  • Jakir Ahmed Chowdhury Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka Dhaka-1000, Bangladesh
  • Abu Asad Chowdhury Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka Dhaka-1000, Bangladesh
  • Shaila Kabir Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka Dhaka-1000, Bangladesh
  • Md Shah Amran Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Banglades

DOI:

https://doi.org/10.3329/bpj.v27i1.71148

Keywords:

Lagenaria siceraria, antioxidant, thrombolytic, anti-inflammatory, membrane stabilizing activity

Abstract

Lagenaria siceraria is a well-known vegetable fruit in Bangladesh. This study aimed to investigate the antioxidant, membrane stabilizing and thrombolytic activities of the ethanolic extract of L. siceraria fruits (EELSF). Total phenolic content and DPPH free radical scavenging activity tests were done to determine antioxidant properties. The anti-inflammatory effects were evaluated using heat- and hypotonic solution induced hemolysis. Human RBC from healthy volunteers were used to assess the thrombolytic activity of the extract. Ethanolic extract of L. siceraria fruits displayed noticeable antioxidant, membrane stabilizing and thrombolytic activities when compared to the standard drugs. Further studies are necessary to evaluate the pharmacological activities of different solvent fractions and plant parts of L. siceraria.

Bangladesh Pharmaceutical Journal 27(1): 1-8, 2024 (January)

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Published

2024-02-11

How to Cite

Sultana, A. ., Sultana, A. ., Aktar, F. ., Chowdhury, J. A. ., Chowdhury, A. A. ., Kabir, S. ., & Amran, M. S. . (2024). In vitro Assessment of Antioxidant, Membrane Stabilization and Thrombolytic Activities of Ethanolic Extract of Lagenaria siceraria Fruit. Bangladesh Pharmaceutical Journal, 27(1), 1–8. https://doi.org/10.3329/bpj.v27i1.71148

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