Assessing Therapeutic Potentials of Catharanthus roseus (L.) G. Don Focusing on Anti-Diabetic, Analgesic and Anti-Diarrheal Activities

Authors

  • Israt Jahan Department of Chemistry, University of Dhaka, Dhaka -1000, Bangladesh
  • Md Hasan Ali Department of Chemistry, University of Dhaka, Dhaka -1000, Bangladesh
  • Nusrat Tabassum Shristy Department of Chemistry, University of Dhaka, Dhaka -1000, Bangladesh
  • Md Omar Sha Rafi Department of Chemistry, University of Dhaka, Dhaka -1000, Bangladesh
  • Sauda Sultana Mimi Department of Chemistry, University of Dhaka, Dhaka -1000, Bangladesh
  • Md Nure Alam Siddik Bangladesh Council of Scientific and Industrial Research (BCSIR), Dr. Qudrat-I-khuda road, Dhanmondi, Dhaka-1205
  • Md Hasanur Rahman Department of Chemistry, University of Dhaka, Dhaka -1000, Bangladesh
  • Mohammad A Rashid Phytochemical Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy University of Dhaka, Dhaka-1000, Bangladesh
  • Tofail Ahmed Chowdhury Department of Chemistry, University of Dhaka, Dhaka -1000, Bangladesh

DOI:

https://doi.org/10.3329/bpj.v27i2.75191

Keywords:

Catharanthus roseus, anti-diabetic, central analgesic, peripheral analgesic, anti-diarrheal.

Abstract

Catharanthus roseus, or 'Nayantara' in Bengali, is a perennial flowering herb. This study aimed to evaluate the pharmacological effectiveness of the plant, focusing on its anti-diabetic, peripheral and central analgesic, and antidiarrheal effects. Methanol soluble partition 200 (MSP-200) and 400 (MSP-400) mg/kg body weight were administered for glucose tolerance test (GTT), heat and chemical-induced response tests, sodium thiosulphate induced test, and castor oil induced test, evaluating anti-diabetic, peripheral and central analgesic, and antidiarrheal effects via in-vivo assay in Swiss-Albino mice model. Methanol soluble partition (MSP) at 200 and 400 mg/kg doses significantly reduced the blood glucose levels of mice by 31.00% and 32.97%, respectively (standard 46.24%). In peripheral analgesic activity, MSP-400 (62.82 ± 4.62%) outperformed MSP-200 (50 ± 3.62%) and MSP-200 (p = 0.0001) exhibited statistically significant central analgesic activity. MSP-400 demonstrated potent anti-diarrheal activity (p = 0.0002). The outcomes from this study put forward a cogent argument that C. roseus plant is capable of producing numerous bioactive compounds such as flavonoids, alkaloids, terpenoids, tannins, etc. which requires systematic phytochemical and pharmacological investigations.

Bangladesh Pharmaceutical Journal 27(2): 215-222, 2024 (July)    

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Published

2024-07-30

How to Cite

Jahan, I., Ali, M. H., Shristy, N. T., Rafi, M. O. S., Mimi, S. S., Siddik, M. N. A., Rahman, M. H., Rashid, M. A., & Chowdhury, T. A. (2024). Assessing Therapeutic Potentials of Catharanthus roseus (L.) G. Don Focusing on Anti-Diabetic, Analgesic and Anti-Diarrheal Activities. Bangladesh Pharmaceutical Journal, 27(2), 215–222. https://doi.org/10.3329/bpj.v27i2.75191

Issue

Vol. 27 No. 2 (2024)

Section

Articles