Alteration of biomarkers of expired and cured COVID- 19 ICU patients in a tertiary care hospital

Alteration of biomarkers of expired

Authors

  • Abu Hasan Senior Scientific Officer, Molecular Diagnostics Lab, Evercare Hospital Dhaka, Plot- 81, Block- E, Bashundhara R/A, Dhaka-1229, Bangladesh
  • Rummana Rahim Specialist, Molecular Diagnostics Lab, Evercare Hospital Dhaka, Plot- 81, Block- E, Bashundhara R/A, Dhaka-1229, Bangladesh
  • Mizanur Rahman Senior Consultant, Molecular Diagnostics Lab, Evercare Hospital Dhaka, Plot- 81, Block- E, Bashundhara R/A, Dhaka-1229, Bangladesh

DOI:

https://doi.org/10.3329/brc.v7i2.54378

Keywords:

COVID-19, SARS-CoV-2, ICU, D-Dimer, CRP, Ferritin, NLR.

Abstract

Coronavirus Disease 2019 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2). This is a retrospective observational study aimed to find the alteration of some biochemical and hematological parameters of 121 COVID-19 patients admitted in intensive care unit (ICU) of Evercare Hospital Dhaka during May to December 2020.

Methods: Retrospective biochemical, hematological and molecular (COVID-19 RT-PCR Ct value) markers were analyzed on COVID-19 patients in ICU and compared on those who died in the ICU and those cured.

Results: Comparison of viral titer assessed by RT-PCR Ct values of target genes of SARS-CoV-2 among cured and expired patients did not show any significant differences. However, biochemical parameters such as CRP, Ferritin and hematological parameters such as WBC, absolute neutrophil, absolute lymphocyte, D-dimer showed significant differences among cured and expired patients. Patients who died in ICU mean CRP, Ferritin, D-dimer, WBC, absolute neutrophil were 10.39, 7694.30, 3196, 16.38, 15.12 respectively, compared to cured patients 0.93, 457.57, 773, 11.24, 8.86 respectively, with 95% confidence interval (95% CI). Platelets and absolute lymphocytes were observed decreased in expired patients compared to cured. Further, elevated level of neutrophil to lymphocyte ratio (NLR) and reduced level of lymphocyte to C-reactive protein ratio (LCR) has significant correlation with disease severity.

Conclusion: These findings indicate that biochemical parameters such as CRP, Ferritin and hematological parameters such as CBC, D-Dimer, NLR, LCR can be monitored to identify severity and fatality of COVID-19 patients and thus, may help in improving disease outcome.

Bioresearch Commu. 7(2): 1031-1037, 2021 (June)

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Published

2021-06-29

How to Cite

Hasan, A., Rahim, R., & Rahman, M. (2021). Alteration of biomarkers of expired and cured COVID- 19 ICU patients in a tertiary care hospital: Alteration of biomarkers of expired. Bioresearch Communications, 7(2), 1031–1037. https://doi.org/10.3329/brc.v7i2.54378

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Original Article