Role of Bronchoalveolar Lavage (BAL) Gene Xpert in Diagnosis of PTB in Sputum Smear Negative Patients

Authors

  • KM Monjurul Alom Assistant Professor (Respiratory Medicine), Shaheed Ziaur Rahman Medical College, Bogura, Bangladesh
  • Mirza Mohammad Idris Ali Assistant Professor (Respiratory Medicine), Cumilla Medical College, Cumilla, Bangladesh
  • Md Jakaria Mahmud Assistant Professor (Respiratory Medicine), M.A.G Osmani Medical College, Sylhet, Bangladesh
  • Md Mohiuddin Ahmed Professor & HOD (Respiratory Medicine), Dhaka Medical College, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/cbmj.v12i1.64292

Keywords:

Xpert MTB/RIF assay, BAL fluid, Sputum, Pulmonary, Tuberculosis

Abstract

The aim of this study was to assess the diagnostic efficacy of Xpert MTB/RIF assay in bronchoalveolar lavage (BAL) in the diagnosis of pulmonary tuberculosis in sputum-smear negative patients. This observational case series study was conducted in a tertiary base institute of Bangladesh from July 2017 to June 2019. All patients with suspected pulmonary tuberculosis who were sputum-smear negative, irrespective of age and gender were included in this study. BAL fluid thus obtained and examined the smear for acid fast bacilli (AFB) and Xpert MTB/RIF assay. The sensitivity, specificity and accuracy values were calculated for smear AFB and Xpert MTB/RIF assay. Xpert MTB/RIF was identified 33 (36.7%) of 90 patients on bronchoalveolar lavage fluid in the final analysis. AFB Fluid culture was positive in 28 (31.2%) cases. The sensitivity and specificity of Xpert MTB/RIF assay was 85.7%, and 85.5% respectively. The positive likelihood ratio was 5.90, and the negative likelihood ratio was 0.167. The accuracy was 85.56%. Xpert MTB/RIF on BAL fluid can be recommended as a fruitful diagnostic tool for mycobacterium pulmonary tuberculosis especially in sputum smear negative, and culture negative patients.

CBMJ 2023 January: Vol. 12 No. 01 P: 60-66

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Published

2023-02-19

How to Cite

Alom, K. M. ., Ali, M. M. I. ., Mahmud, M. J. ., & Ahmed, M. M. . (2023). Role of Bronchoalveolar Lavage (BAL) Gene Xpert in Diagnosis of PTB in Sputum Smear Negative Patients. Community Based Medical Journal, 12(1), 60–66. https://doi.org/10.3329/cbmj.v12i1.64292

Issue

Vol. 12 No. 1 (2023)

Section

Original Articles

License

Copyright (c) 2023 KM Monjurul Alom, Mirza Mohammad Idris Ali, Md Jakaria Mahmud, Md Mohiuddin Ahmed

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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