Early Detection of Central Pontine Myelinolysis with MRI: A Case Study

Authors

  • Goutam Chowdhury Chevron Clinical Laboratory Chittagong
  • Abdul Ahad Mohammed Ryhan Uddin University of Science & Technology Chittagong Chittagong
  • Md. Abdur Rouf University of Science & Technology Chittagong Chittagong
  • Rajat Sanker Roy Biswas Chattagram International Dental College & Hospital & International Islamic Medical College & Hospital Chittagong
  • Md. Ismail University of Science & Technology Chittagong Chittagong
  • Md. Siraj University of Science & Technology Chittagong Chittagong
  • Mohammed Musfequr Rahman Chittagong Medical College Chittagong

DOI:

https://doi.org/10.3329/cmoshmcj.v13i1.19427

Keywords:

Magnetic resonance imaging, central pontine myelinolysis, hyponatremia

Abstract

Central pontine myelinolysis (CPM) is a complication of treatment of patients with severe hyponatremia. The microscopic appearance of central pontine myelinolysis is loss of myelin with sparing of axons, without evidence of inflammation. The abnormalities associated with central pontine myelinolysis are readily identified on magnetic resonance imaging scans. A patient with central pontine myelinolysis following rapid correction of hyponatremia was studied with magnetic resonance imaging soon after onset of tetraplegia & dysarthria. Affected central pontine white matter showed restricted diffusion on diffusion-weighted images associated with hyper signal on T2-W & FLAIR images. MRI with dedicated sequences is the modality of choice for early detection of osmotic changes in the brain.

DOI: http://dx.doi.org/10.3329/cmoshmcj.v13i1.19427

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Author Biographies

Goutam Chowdhury, Chevron Clinical Laboratory Chittagong

Department of Radiology and Imaging

Abdul Ahad Mohammed Ryhan Uddin, University of Science & Technology Chittagong Chittagong

Department of Medicine and Critical Care Unit

Md. Abdur Rouf, University of Science & Technology Chittagong Chittagong

Department of Medicine and Cardiology

Rajat Sanker Roy Biswas, Chattagram International Dental College & Hospital & International Islamic Medical College & Hospital Chittagong

Department of Medicine

Md. Ismail, University of Science & Technology Chittagong Chittagong

Department of Dermatology

Md. Siraj, University of Science & Technology Chittagong Chittagong

Department of Medicine

Mohammed Musfequr Rahman, Chittagong Medical College Chittagong

Department of Anaesthesiology

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Published

2015-01-09

How to Cite

Chowdhury, G., Ryhan Uddin, A. A. M., Rouf, M. A., Biswas, R. S. R., Ismail, M., Siraj, M., & Rahman, M. M. (2015). Early Detection of Central Pontine Myelinolysis with MRI: A Case Study. Chattagram Maa-O-Shishu Hospital Medical College Journal, 13(1), 70–72. https://doi.org/10.3329/cmoshmcj.v13i1.19427

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Section

Case Reports