Impact of Urinary Tract Infection on Steroid Response in Idiopathic Nephrotic Syndrome in Children

Authors

  • Tanuka Barua Chattagram Maa-O-Shishu Hospital Medical College, Chittagong
  • Razia Sultana Chittagong Medical College, Chittagong
  • Pradip Kumar Datta Chittagong Medical College, Chittagong
  • Jhulan Das Sharma Southern Medical College, Chittagong
  • Md Rezaul Karim Chittagong Medical College, Chittagong
  • Mainuddin Ahmad Dhaka Medical College, Dhaka

DOI:

https://doi.org/10.3329/cmoshmcj.v13i2.21046

Keywords:

Nephrotic syndrome, UTI, proteinuria

Abstract

Context: UTI is one of the most common infection in nephrotic syndrome and may be a cause of delayed steroid response. Objective:To observe the impact of urinary tract infection on steroid response in idiopathic nephrotic syndrome children aged 2-6 years.

Study design: Quasi experimental study Study period & place: Pediatric ward of Chittagong Medical College Hospital, Chittagong from 01.01.2009 to 31.12.2009. Participants: 52 Nephrotic syndrome children aged 2-6 years with typical clinical features Group A: Nephrotic syndrome with UTI, Group B: Nephrotic syndrome without UTI. Methods: Heat coagulation test, urine for R/M/E and C/S was done in every patient. Steroid was given according to standard regimen. Date of starting of steroid was recorded. Antibiotic was given in group A cases according to C/S report. Patients were followed for clinical and urinary remission. Group A and B were compared for remission time achieved by statistical method.

Results: A male preponderance was noted about 57.7% against female about 42.3%. Generalized swelling of body & scanty micturation found in cent percent study group. Ascitis was found in 23.08%. Scrotal/labial swelling 7.69%.UTI developed in 30.8% of patients of NS. Male female ratio is 1:1. Infection delayed the remission of proteinuria. Mean remission time of NS without UTI patients was 7.39 days and with UTI patients was 9.31 days. In statistical analysis, mean remission time in group A =9.31+2.24 days(mean + SD), in group B=7.39+2.51 days(mean + SD), P value = <0.05, statistically significant.

Conclusion: UTI in nephrotic syndrome causes delayed remission of proteinuria and may be asymptomatic.It should be screened in every nephrotic syndrome children routinely.

DOI: http://dx.doi.org/10.3329/cmoshmcj.v13i2.21046

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Author Biographies

Tanuka Barua, Chattagram Maa-O-Shishu Hospital Medical College, Chittagong

Department of Pediatrics

Razia Sultana, Chittagong Medical College, Chittagong

Shishu Bikash Kendra

Pradip Kumar Datta, Chittagong Medical College, Chittagong

Department of Nephrology

Jhulan Das Sharma, Southern Medical College, Chittagong

Department of Pediatrics

Md Rezaul Karim, Chittagong Medical College, Chittagong

Department of Pediatrics

Mainuddin Ahmad, Dhaka Medical College, Dhaka

Department of Pediatrics

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Published

2014-11-30

How to Cite

Barua, T., Sultana, R., Datta, P. K., Sharma, J. D., Rezaul Karim, M., & Ahmad, M. (2014). Impact of Urinary Tract Infection on Steroid Response in Idiopathic Nephrotic Syndrome in Children. Chattagram Maa-O-Shishu Hospital Medical College Journal, 13(2), 1–3. https://doi.org/10.3329/cmoshmcj.v13i2.21046

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Section

Original Articles