Prevalence of Extended Spectrum b-Lactamases (ESBLs) Producers Among Gram-Negative Bacilli in Urinary Tract Infections

Authors

  • Abu Hena Md Saiful Karim Chowdhury Department of Clinical Pathology, Chittagong Medical College, Chittagong
  • Md Anwar Husain Department of Microbiology, Chittagong Medical College, Chittagong
  • Nasima Akter Department of Microbiology, Chittagong Medical College, Chittagong
  • Md Abdul Mazed Department of Microbiology, Chittagong Medical College, Chittagong
  • Shakeel Ahmed Department of Microbiology, Chittagong Medical College, Chittagong
  • Tipu Sultan Department of Virology, Rangamati Medical College, Rangamati
  • Arup Kanti Dewanjee Department of Microbiology, Abdul Malek Ukil Medical College, Noakhali
  • Sanjoy Kanti Biswas Department of Microbiology, Chattagram Maa-O-Shisu Hospital Medical College Chittagong
  • ASM Ashanul Karim Department of Medicine, University of Science & Technology Chittagong (USTC), Chittagong
  • Sheikh Khairul Kabir Department of Medicine, Chittagong Medical College, Chittagong

DOI:

https://doi.org/10.3329/cmoshmcj.v14i2.25711

Keywords:

ESBLs, Gram Negative Bacilli, Urinary Tract Infection (UTI), Minimum Inhibitory Concentration (MIC)

Abstract

Background: Antimicrobial resistance is now proclaimed as the most important challenge worldwide being faced by humanity in its fight against infectious diseases. Extended Spectrum b-Lactamases (ESBLs) producing organisms are increasing in number and causing more severe infections because of their continuous mutation and multidrug resistance property which make its treatment difficult.

Aims: The present study was undertaken to detect the prevalence of the ESBLs producing bacteria in urinary tract infection.

Methods: Isolated gram-negative bacteria initially screened by Minimum Inhibitory Concentration (MIC) ESBLs breakpoints. Then suspected ESBLs producers were confirmed by phenotypic confirmatory test.

Results: 71 (59.17%) bacterial strains were isolated from 120 urine samples of patients of suspected urinary tract infection of which 66(92.96%) were gram-negative and 05(07.04%) were gram-positive. Among the isolated gram-negative bacteria 63(95.45%) were found suspected ESBLs producers of which 35(55.56%) were found as confirmed ESBL producers. The prevalence of ESBLs producing organisms in the present study were found to be 53.03% and Klebsiella spp. as most prevalent ESBLs producers.

Conclusion: It is essential to report ESBL production along with routine sensitivity reporting, which will help the clinician in prescribing the proper antibiotics.

Chatt Maa Shi Hosp Med Coll J; Vol.14 (2); Jul 2015; Page 17-20

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Author Biography

Abu Hena Md Saiful Karim Chowdhury, Department of Clinical Pathology, Chittagong Medical College, Chittagong



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Published

2015-11-16

How to Cite

Karim Chowdhury, A. H. M. S., Husain, M. A., Akter, N., Mazed, M. A., Ahmed, S., Sultan, T., Dewanjee, A. K., Biswas, S. K., Karim, A. A., & Kabir, S. K. (2015). Prevalence of Extended Spectrum b-Lactamases (ESBLs) Producers Among Gram-Negative Bacilli in Urinary Tract Infections. Chattagram Maa-O-Shishu Hospital Medical College Journal, 14(2), 17–20. https://doi.org/10.3329/cmoshmcj.v14i2.25711

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