Role of Hematological Score in Early Diagnosis of Neonatal Sepsis

Authors

  • Dipika Dey Assistant Professor, Department of Neonatology, Chattogram Maa-O-Shishu Hospital Medical College Chattogram, Bangladesh
  • Razia Sulltana Department of Pathology, Chattogram Maa-O-Shishu Hospital Medical College, Chattogram, Bangladesh
  • Wazir Ahmed Head of Institute of Child Health, Chattogram Maa-O-Shishu General Hospital Medical College, Chattogram, Bangladesh
  • Mahmood Ahmed Chowdhury Department of Paediatrics, Chattogram Maa-O-Shishu Hospital Medical College, Chattogram, Bangladesh
  • Farhana Akter Department of Neonatology, Chattogram Maa-O-Shishu Hospital Medical College, Chattogram, Bangladesh
  • Srabony Dasgupta Department of Neonatology, Chattogram Maa-O-Shishu Hospital Medical College, Chattogram, Bangladesh

DOI:

https://doi.org/10.3329/cmoshmcj.v18i2.47776

Keywords:

Neonatal sepsis; Blood culture; Hematological scoring system

Abstract

Background: Neonatal sepsis is one of the major causes of morbidity & mortality in the newborn, more so in the developing countries.

Objective: The objective of this study was to evaluate the applicability of Haematological Scoring System (HSS) in early diagnosis of sepsis and its compatibility with C-reactive protein (CRP) and blood culture.

Materials and methods: This prospective study consisted of 205 neonates admitted at neonatal intensive care unit of Chattogram Maa-shishu-o General Hospital with clinical suspicion of neonatal sepsis, from July 2017 to December 2017. The neonatal hematological parameter was measured in all cases. Blood culture and CRP estimation were also performed. Blood culture is considered as gold standard for diagnosis of sepsis. Score 3 and more was considered as positive

Results: Out of 205 neonates of our study population, forty one (20%) had proven sepsis according to culture. Total leukocyte count showed high sensitivity & least specificity, immature to mature neutrophil ratio showed high sensitivity and high specificity. Platelet count showed high negative predictive value and least positive predictive value. The HSS was found to have a sensitivity of 82.9%, specificity of 79.8%, positive predictive value was 50.74% and negative predictive value was 94.92%. Considering the high sensitivity and negative predictive value, this study implies that score ³3 were more reliable as a screening tool for sepsis than any of the individual hematological parameter.

Conclusion: HSS is a simple, easy and rapid adjunct for the diagnosis of clinically suspected cases of neonatal sepsis. It also provides an effective guideline to make decisions regarding judicious use of antibiotic therapy.

Chatt Maa Shi Hosp Med Coll J; Vol.18 (2); July 2019; Page 45-48

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Published

2020-06-24

How to Cite

Dey, D., Sulltana, R., Ahmed, W., Chowdhury, M. A., Akter, F., & Dasgupta, S. (2020). Role of Hematological Score in Early Diagnosis of Neonatal Sepsis. Chattagram Maa-O-Shishu Hospital Medical College Journal, 18(2), 45–48. https://doi.org/10.3329/cmoshmcj.v18i2.47776

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Original Articles