Optimization of the bioequivalence study of esomeprazole capsule contents after in vitro suspension in soft foods using HPLC

Authors

  • M Alauddin Department of Biochemistry and Molecular Biology, University of Dhaka
  • KMZ Hossain Faculty of Science and Information Technology, Daffodil International University, Dhaka
  • MA Rahman Faculty of Science and Information Technology, Daffodil International University, Dhaka
  • ASMH Kabir Department of Applied Chemistry and Chemical Technology, University of Dhaka
  • IH Khan Department of Microbiology, University of Dhaka

DOI:

https://doi.org/10.3329/diujst.v4i2.4368

Keywords:

Bioequivalence, Esomeprazole pellets, Soft foods, Gastric environment, Dissolution

Abstract

A bioequivalence study for the selection of the alternative and feasible mode of administration of esomeprazole pellets suspended in some common soft liquid foods has been done. 20 mg of four different brands esomeprazole pellets suspended in yogurt, orange juice, apple juice and milk were analyzed in the gastric environment using dissolution tester and high performance liquid chromatography. The release of the esomeprazole active was found more the 90% using these liquid foods except milk. The optimal release of the active was found in the system of apple juice (97.06%). Administration of the esomeprazole pellets suspending in apple juice may be a practical alternative for patients who cannot swallow an intact capsule.

Keywords: Bioequivalence, Esomeprazole pellets, Soft foods, Gastric environment, Dissolution.

DOI: 10.3329/diujst.v4i2.4368

Daffodil International University Journal of Science and Technology Vol.4(2) 2009 pp.59-61

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How to Cite

Alauddin, M., Hossain, K., Rahman, M., Kabir, A., & Khan, I. (2010). Optimization of the bioequivalence study of esomeprazole capsule contents after in vitro suspension in soft foods using HPLC. Daffodil International University Journal of Science and Technology, 4(2), 59–61. https://doi.org/10.3329/diujst.v4i2.4368

Issue

Vol. 4 No. 2 (2009)

Section

Papers

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