A young lady with primary amenorrhea and virilization

Authors

  • Muhammad Abdul Halim Khan Associate Professor, Department of Endocrinology, Shaheed Suhrawardy Medical College & Hospital, Dhaka, Bangladesh
  • Md Shahed Morshed PhD student, Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh
  • Nusrat Sultana Associate Professor, Department of Endocrinology, BSMMU, Dhaka, Bangladesh
  • Sharmin Jahan Associate Professor, Department of Endocrinology, BSMMU, Dhaka, Bangladesh
  • Yasmin Aktar Assistant Professor, Department of Endocrinology, Bangladesh Medical College Hospital, Dhaka, Bangladesh
  • Md Fariduddin Professor, Department of Endocrinology, BSMMU, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/jacedb.v3i1.78623

Keywords:

Virilization, Adrenal adenoma, Dehydroepiandrosterone-sulfate, Adrenalectomy

Abstract

An 18-year-old female presented with primary amenorrhea, absent development of breasts, and features of virilization. Investigations revealed high total testosterone and dehydroepiandrosterone-sulfate with normal cortisol and 17-hydroxyprogesterone. Her karyotype was 46XX. CT scan of the abdomen revealed a (4×3) cm sized left adrenal mass. Open adrenalectomy followed by histopathology of the resected adrenal showed a benign adenoma. The patient’s clinical and biochemical features improved within six months of surgery. Virilization usually indicates a malignant adrenal tumor, but surprisingly the cause may be a benign one.

J Assoc Clin Endocrinol Diabetol Bangladesh, January 2024; 3 (1): 31-33

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Published

2025-02-17

How to Cite

Khan, M. A. H., Morshed, M. S., Sultana, N., Jahan, S., Aktar, Y., & Fariduddin, M. (2025). A young lady with primary amenorrhea and virilization. Journal of Association of Clinical Endocrinologist and Diabetologist of Bangladesh, 3(1), 31–33. https://doi.org/10.3329/jacedb.v3i1.78623

Issue

Vol. 3 No. 1 (2024)

Section

Case Report

License

Copyright (c) 2024 Muhammad Abdul Halim Khan, Md Shahed Morshed, Nusrat Sultana, Sharmin Jahan, Yasmin Aktar, Md Fariduddin

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.