Performance of ESAT-6 for serodiagnosis of nonhuman primate tuberculosis: A meta-analysis

Authors

  • Fangui Min Guangdong Laboratory Animals Monitoring Institute, Guangdong Provincial Key Laboratory of Laboratory Animals, Guangzhou 510663
  • Jing Wang Guangdong Laboratory Animals Monitoring Institute, Guangdong Provincial Key Laboratory of Laboratory Animals, Guangzhou 510663
  • Yu Zhang Guangdong Laboratory Animals Monitoring Institute, Guangdong Provincial Key Laboratory of Laboratory Animals, Guangzhou 510663

Keywords:

ESAT-6, Meta analysis, Nonhuman primate, Serodiagnosis, Tuberculosis

Abstract

ESAT-6 is one of the most studied antigens in vaccine, diagnosis, and pathogenic mechanism of tuberculosis. In the present study, a meta-analysis was performed regarding the use of ESAT-6 based antibody detection test for diagnosing nonhuman primate (NHP) tuberculosis. Studies in English and Chinese were searched and selected strictly. Quality of included studies was assessed using the standardized QUADAS-2 tool. Heterogeneity was explored through meta-regression. Finally, eight studies were included with high degree of homogeneity. Quality of included studies was general satisfied except the bias of patient selection for the majority of serum samples were from experimental infections. Estimates of sensitivity ranged from 69% to 82%, while specificity ranged from 96% to 99%. Area under ROC curves and Q were 0.9503 and 0.8909 respectively, indicating a high diagnostic accuracy. Current evidence suggests that ESAT-6 based serodiagnosis has the potential to become useful diagnostic tools for NHP tuberculosis.

 

http://dx.doi.org/10.5455/javar.2015.b58

 

Downloads

Download data is not yet available.
Abstract
708
PDF
470

Downloads

Published

2015-05-20

How to Cite

Min, F., Wang, J., & Zhang, Y. (2015). Performance of ESAT-6 for serodiagnosis of nonhuman primate tuberculosis: A meta-analysis. Journal of Advanced Veterinary and Animal Research, 2(2), 107–114. Retrieved from https://banglajol.info/index.php/JAVAR/article/view/23200

Issue

Vol. 2 No. 2 (2015)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).