Trypanosoma evansi causes thyroxin imbalance with biochemical alterations in wistar rats

Authors

  • Sirigireddy Sivajothi Department of Veterinary Parasitology, College of Veterinary Science, Tirupati
  • V. C. Rayulu Department of Veterinary Parasitology, College of Veterinary Science, Tirupati
  • Bhavanam Sudhakara Reddy Department of Veterinary Medicine, College of Veterinary Science, Tirupati
  • Karumuri Nalini Kumari Nalini Kumari Department of Veterinary Medicine, College of Veterinary Science, Tirupati

Keywords:

Anemia, Biochemical alterations, India, Rats, Trypanosoma evansi, Thyroxin

Abstract

Animals affected with Trypanosoma evansi show rare serum hormonal disturbances. One of the important hormones for livestock is thyroxin, and the level of thyroxin may be reduced during the T. evansi infection. The objective of the study was to investigate thyroxin level during experimentally induced T. evansi infection in Wister albino rats. Wistar albino white rats (n=12) were challenged with the local strain of T. evansi (at 5x105 trypanosomes/animal subcutaneously). At the high parasitemia, blood was collected from the rats, and serum was separated, which was subjected for biochemical evaluation. Decreased total serum thyroxin (2.91 ±0.04 µg/dL) and free thyroxin (1.30 ±0.05 ng/dL) levels (p<0.01) were recorded in T. evansi infected rats as compared to the control group of rats. Along with lowered thyroxin levels, decreased levels of total erythrocyte count, packed cell volume, hemoglobin, total leucocyte count, total serum proteins, albumin and glucose levels were recorded. On the other hand, significant increase (p<0.01) in cholesterol, blood urea nitrogen, serum alkaline phosphatase, serum aspartate aminotransferase, and serum alanine aminotransferase levels were observed. Thus, it is concluded that trypanosomiasis induces stress on rat, which have direct effect on thyroid hormone.

http://dx.doi.org/10.5455/javar.2015.b68

 


Downloads

Download data is not yet available.
Abstract
168
PDF
73

Downloads

Published

2015-05-20

How to Cite

Sivajothi, S., Rayulu, V. C., Reddy, B. S., & Kumari, K. N. K. N. (2015). Trypanosoma evansi causes thyroxin imbalance with biochemical alterations in wistar rats. Journal of Advanced Veterinary and Animal Research, 2(2), 205–209. Retrieved from https://banglajol.info/index.php/JAVAR/article/view/23221

Issue

Vol. 2 No. 2 (2015)

Section

Short Communications

License

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).