Effects of maintenance of propofol-ketamine anesthesia with repeat bolus and constant rate infusion of propofol on physiological, biochemical, anesthetic and analgesic indices in dogs

Abstract

The  research  work  was  aimed  at  investigating
physiological,  biochemical,  analgesic  and  anesthetic
indices of dogs anesthetized with propofol-ketamine
and  maintained  with  repeat  bolus  and  constant
infusions  of  propofol.  Eight  dogs,  assigned  to  two
groups (n=4), were used in this study. All dogs were
pre-medicated with atropine (at 0.03 mg/kg bwt) and
xylazine (at 2 mg/kg bwt). Anesthesia was induced by
a  concurrent  administration  of  propofol  (at  4  mg/kg
bwt)  and  ketamine  (at  2.5  mg/kg  bwt).  Maintenance
of  anesthesia  in  Group  1  was  done  with  a  repeat
bolus of propofol (at 2 mg/kg bwt), while in Group 2
it was  done with a constant infusion of propofol (at
0.2  mg/kg  bwt/min).  Gastrotomy  was  performed  in
both  groups,  and  anesthesia  was  maintained  for  60
min.  Physiological,  analgesic,  anesthetic  parameters
and  plasma  glucose  concentration  were  measured.
There was no significant (P>0.05) difference found in
the  analgesia  and  pedal  reflex  scores,  durations  of 
analgesia  and  recumbency,  recovery  time  and
standing  time  between  the  groups.  The  heart  rate,
respiratory  rate  and  rectal  temperature  reduced
significantly  (P<0.05)  from  the  baseline  values.  The
heart and respiratory rates were significantly (P<0.05)
lowered  in  Group  1  than  in  Group  2.  Blood  glucose
was  significantly  (P<0.05)  elevated  at  recovery  from
anesthesia  in  both  groups.  However,  the  value  did
not differ significantly (P>0.05) between the groups.
In  conclusion,  both  maintenance  protocols  are
suitable  for  dogs,  although  the  repeat  bolus
technique  produces  marked  cardiopulmonary
depression.

http://dx.doi.org/10.5455/javar.2015.b114