Assessment of immune response in cattle against experimentally prepared trivalent (O, A, and Asia-1) FMD vaccine in Bangladesh

Authors

  • Md. Mashfiqur Rahman Chowdhury Department of Microbiology and Hygiene, FVS, BAU, Mymensingh
  • Md. Liakot Hossen Department of Microbiology and Hygiene, Bangladesh Agricultural Unviersity, Mymensingh-2202
  • Khaled Bin Amin Department of Microbiology and Hygiene, Bangladesh Agricultural Unviersity, Mymensingh-2202
  • K. H. M. Nazmul Hussain Nazir Department of Microbiology and Hygiene, Bangladesh Agricultural Unviersity, Mymensingh-2202
  • Sultan Ahmed Department of Microbiology and Hygiene, Bangladesh Agricultural Unviersity, Mymensingh-2202
  • Marzia Rahman Department of Microbiology and Hygiene, Bangladesh Agricultural Unviersity, Mymensingh-2202
  • Mohammad Ferdousur Rahman Khan Department of Microbiology and Hygiene, Bangladesh Agricultural Unviersity, Mymensingh-2202
  • Md. Tanvir Rahman Department of Microbiology and Hygiene, Bangladesh Agricultural Unviersity, Mymensingh-2202
  • Md. Bahanur Rahman Department of Microbiology and Hygiene, Bangladesh Agricultural Unviersity, Mymensingh-2202

Keywords:

Age, Cattle, ELISA, FMDV, FMD vaccine

Abstract

This research work was conducted to investigate the
effects  of  age,  sex  and  breed  on  the  induction  of
immune  response  against  experimentally  prepared
inactivated  trivalent  (type  O,  A,  and  Asia-1)  FMD
vaccine. Twenty six cattle were divided into four test
groups (Group A, B, C, and D; 5 cattle in each group)
and one control group (n=6) based on breed (local and
cross),  age  (?12  months  and  >12  months),  and  sex
(male  and  female).  Test  cattle  were  vaccinated  with
the  experimentally  prepared  trivalent  FMD  vaccine.
Pre-  and  post  vaccinated  sera  from  the  vaccinated
cattle were collected upto 63 days, and the sera were
tested  using  liquid  phase  blocking  enzyme  linked
immunosorbent  assay  (LPBE)  that  was  specific  for
FMD  serotypes  O,  A,  and  Asia-1.  Antibody  titers  of
all  the  pre-vaccinated  serum  samples  were  found  to
be under protection level. The females were found to
be more protected (90%; n=9/10) as compared to males
(70%;  n=7/10).  The  titers  obtained  were  statistically
analyzed  using  ttest  to  observe  the  effects  of  age,
breed and sex. It was observed that the mean values
of antibody titer in cattle aging >12 months against O,
A,  and  Asia-1  serotypes  were  significant  (P<0.05)  at
21, 49 and 63 days as compared to the values obtained
from the cattle aging ?12 months. In conclusion, the
local  female  cattle  aging  >12  months  showed  better
immune response towards trivalent FMD vaccine.

 

http://dx.doi.org/10.5455/javar.2015.b121      

 

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Published

2015-12-31

How to Cite

Chowdhury, M. M. R., Hossen, M. L., Amin, K. B., Nazir, K. H. M. N. H., Ahmed, S., Rahman, M., Khan, M. F. R., Rahman, M. T., & Rahman, M. B. (2015). Assessment of immune response in cattle against experimentally prepared trivalent (O, A, and Asia-1) FMD vaccine in Bangladesh. Journal of Advanced Veterinary and Animal Research, 2(4), 475–480. Retrieved from https://banglajol.info/index.php/JAVAR/article/view/26097

Issue

Vol. 2 No. 4 (2015)

Section

Original Articles

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