Evaluation of anesthesia produced by ketofol in acepromazine- or medetomidine-sedated dogs

Authors

  • Moses Njino Wamaitha Department of Clinical Studies, Faculty of Veterinary Medicine, University of Nairobi, Nairobi, Kenya
  • Eddy M Mogoa Department of Clinical Studies, Faculty of Veterinary Medicine, University of Nairobi, Nairobi, Kenya
  • John D Mande Department of Clinical Studies, Faculty of Veterinary Medicine, University of Nairobi, Nairobi, Kenya

Keywords:

Acepromazine; medetomidine; ketofol; anesthesia; analgesia

Abstract

Objective: A randomized, blinded clinical study was conducted to evaluate ketofol (Ketamine + Propofol combination) anesthesia in 12 entire male mongrel dogs sedated with either aceproma­zine (ACP) or medetomidine.

Materials and Methods: Group A (6) dogs were pre-medicated with ACP and Group B (6) dogs with medetomidine. Anesthesia was induced and maintained using ketofol (ketamine and propo­fol). Routine open pre-scrotal castration was performed. Sedation score and ease of arousal were assessed and recorded. Duration and depth of anesthesia were evaluated using apnea and the absence of palpebral and pedal reflexes, attempts to stand up, and muscle tremors and post-operative pain. Simple statistics were compared using Student t-test and Mann–Whitney test (p < 0.05).

Results: Medetomidine-sedated dogs had higher sedation scores compared to ACP-sedated dogs. Medetomidine-ketofol produced significantly (p < 0.05) longer duration of anesthesia (24.5 ± 3.1 min) compared to ACP-ketofol (10.0 ± 4.4 min). Sixty-seven percent of dogs anesthetized with ACP-ketofol required top up with ketofol to complete the castration. However, none of the Med-ketofol anesthetized dogs required top up. Med-ketofol produced a more profound depth of anes­thesia and smoother recovery from anesthesia compared to ACP-ketofol. Med-ketofol (median score 6) attained better overall post-operative analgesia compared to ACP-ketofol (median score 7), though not statistically significant (p = 0.25). Although both protocols provided adequate anes­thesia for castration, top up was required to complete the operation in more than half of ACP-ketofol anesthetized dogs, making Med-ketofol a better protocol.

Conclusion: The study recommends the use of Med-ketofol anesthesia for castration in a dog, and post-operative analgesia to be administered with either protocol, but more so in ACP-ketofol anesthetized dogs undergoing castration.

J. Adv. Vet. Anim. Res., 6(2): 215-221, June 2019

Downloads

Download data is not yet available.
Abstract
14
PDF
26

Downloads

Published

2019-06-13

How to Cite

Wamaitha, M. N., Mogoa, E. M., & Mande, J. D. (2019). Evaluation of anesthesia produced by ketofol in acepromazine- or medetomidine-sedated dogs. Journal of Advanced Veterinary and Animal Research, 6(2), 215–221. Retrieved from https://banglajol.info/index.php/JAVAR/article/view/41763

Issue

Vol. 6 No. 2 (2019)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).