Hypoglycemic and hypolipidemic effects of two mangrove plants in a streptozotocininduced animal model of diabetes

Authors

  • Isam ELDin Mohamed ELAmin Abu Zeid Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudia Arabia.
  • Obidallah Hamdan Ali Al Jaghthmi Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudia Arabia.

Keywords:

Diabetic rats; R. mucronata; glucose; A. marina; insulin; lipid profile

Abstract

Objective: This study aims at evaluating the anti-diabetic, hypolipidemic, and pancreatic histo­pathological changes of Rhizophora mucronata and Avicennia marina.  Materials and Methods: The experimental rats were divided into eight groups (n = 15 each). Streptozotocin was used to induce diabetes. Daily oral administration of an aqueous extract from the leaves of R. mucronata and A. marina at 400 mg/kg BW, and a mixture of the two extracts for 6 weeks was assessed. The measurements of serum glucose, insulin, and lipid profile were carried out. Pancreatic specimens were collected from all groups and processed for pathological studies.  Results: The study revealed that the plant extracts restored the levels of diabetic markers and lipid profiles of diabetic rats, with no significant changes in non-diabetic ones. The extract of R. mucronata exhibited more promising anti-diabetic and hypolipidemic effects than A. marina singly or combined.  Conclusion: Leaf extracts from R. mucronata, singly or combined, and A. marina, induced a potent anti-diabetic and hypolipidemic potential in diabetic rats.

J. Adv. Vet. Anim. Res., 7(3): 421-428, Sep 2020

http://doi.org/10.5455/javar.2020.g437

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Published

2020-08-03

How to Cite

ELAmin Abu Zeid, I. E. M., & Jaghthmi, O. H. A. A. (2020). Hypoglycemic and hypolipidemic effects of two mangrove plants in a streptozotocininduced animal model of diabetes. Journal of Advanced Veterinary and Animal Research, 7(3), 421–428. Retrieved from https://banglajol.info/index.php/JAVAR/article/view/75595

Issue

Vol. 7 No. 3 (2020)

Section

Original Articles

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Copyright (c) 2020 Isam ELDin Mohamed ELAmin Abu Zeid, Obidallah Hamdan Ali Al Jaghthmi

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