Gastric histopathological features after the administration of omeprazole, amoxicillin, and clarithromycin in gastritis Helicobacter pylori rat model

Authors

  • OK Yulizal Department of Internal Medicine, Faculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia.
  • Setia Budi Tarigan Faculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia.
  • OK Isnainul Postgraduate School, Universitas Prima Indonesia, Medan, Indonesia.
  • Zainul Muttaqin Biomedical Research Unit, West Nusa Tenggara General Hospital, Lombok, Indonesia.

Keywords:

Gastritis; Helicobacter pylori; Histopathological features; Omeprazole; Amoxicillin; Clarithromycin

Abstract

Objective: This research work aimed to assess the histopathological features and degree of gas­tritis severity in a rat model, induced by Helicobacter pylori infection after administering omepra­zole, amoxicillin, and clarithromycin as the standard first-line eradication regimen.  Material and Methods: Twenty-one male rats were adapted for 7 days and randomly divided into three equal groups. Group 1 was considered a negative control. Group 2 and Group 3 were treated as H. pylori-inoculated groups. Group 2 was set as a positive control. Group 3 was admin­istered omeprazole, amoxicillin, and clarithromycin as a first-line eradication regimen. Gastric histopathological examination was conducted. The difference in the severity of gastritis among the groups was examined using the one-way analysis of variance test. The significance was deter­mined to be p < 0.05.  Results: Gastritis was found in all inoculated groups. The severity of gastritis was highest in Group 2 (p < 0.05). We could see a refinement in gastritis severity after administering omeprazole, amox­icillin, and clarithromycin as a first-line eradication regimen (Group 3 vs. Group 2; p <0.05).  Conclusion: Gastritis, induced by the H. pylori rat model, was found in all inoculated groups. There was a refinement in the degree of gastritis severity after the administration of omeprazole, amox­icillin, and clarithromycin as a first-line eradication regimen.

J. Adv. Vet. Anim. Res., 8(1): 158-163, Mar 2021

http://doi.org/10.5455/javar.2021.h498

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Published

2021-03-09

How to Cite

Yulizal, O., Tarigan, S. B., Isnainul, O., & Muttaqin, Z. (2021). Gastric histopathological features after the administration of omeprazole, amoxicillin, and clarithromycin in gastritis Helicobacter pylori rat model. Journal of Advanced Veterinary and Animal Research, 8(1), 158–163. Retrieved from https://banglajol.info/index.php/JAVAR/article/view/76039

Issue

Vol. 8 No. 1 (2021)

Section

Original Articles

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Copyright (c) 2021 OK Yulizal, Setia Budi Tarigan, OK Isnainul, Zainul Muttaqin

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