Parameters of nonspecific resistance of calves with respiratory pathology before and after treatment

Authors

  • Hamdan Naef Department of Veterinary Medicine, Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia.
  • Mohammad Abed Alhussen Department of Veterinary Medicine, Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia.
  • Yury Anatolyevich Vatnikov Department of Veterinary Medicine, Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia.
  • Liliya Valeryevna Cheskidova Federal State Budgetary Scientific Institution, Russian Ministry of Agriculture, All-Russian Veterinary Research Institute of Pathology, Pharmacology and Therapy, Farong, Russia.
  • Valentina Ivanovna Semenova Department of Veterinary Medicine, Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia.
  • Pavel Andreevich Parshin Federal State Budgetary Scientific Institution, Russian Ministry of Agriculture, All-Russian Veterinary Research Institute of Pathology, Pharmacology and Therapy, Farong, Russia.
  • Mohammad Almohammad Alsalh Department of Animal Husbandry, College of Veterinary Medicine, Al Furat University, Deirez-Zor, Syria.

Keywords:

Respiratory diseases; natural resistance; treatment; calves

Abstract

Objective: The research was conducted to study the effect of a complex antimicrobial drug with an anti-inflammatory effect and an antimicrobial drug with an immunostimulating effect on the parameters of nonspecific resistance in calves.  Materials and Methods: Two groups (n = 5 each) of sick calves with respiratory pathology were selected for this study. For the treatment of the first experimental group, a complex antimicro­bial drug Sulfetrisan® was used. The second experimental group of the calves was intramuscu­larly injected with the experimental drug gentaaminoseleferon (GIA). To assess the cellular com­ponent of immunity in the blood before and after treatment, the number of white blood cells, T-lymphocytes, B-lymphocytes, phagocytic activity of leukocytes, phagocytic number, and phago­cytic index (PhI) were determined. In addition, for assessing the humoral component, serum complement activity (SCA), serum lysozyme activity, serum bactericidal activity (SBA), circulating immune complexes (CIC), and total immunoglobulins (total Ig) were measured. The results were compared with the baseline parameters of healthy calves of the control group.  Results: When studying the parameters of the humoral and cellular components of nonspecific resistance, it was found that in sick animals, compared with healthy ones, respiratory pathology was accompanied by an imbalance in the immune system. In the process of recovery in animals of the experimental groups under the effect of the drugs, positive changes occurred. However, many of the studied parameters did not reach the values of healthy animals. In the group of calves that received GIA, compared with the calves given Sulfetrisan®, a significant increase in PhI (p < 0.05), SBA (p < 0.006), SCA (p < 0.05), total Ig (p < 0.0005), and CIC (p < 0.05) was observed, which indi­cated an increase in natural resistance due to the immunostimulating action.  Conclusion: The use of GIA in sick animals added to an increase in the general nonspecific cellular and humoral resistance of calves, which made it possible to increase therapeutic efficacy and shorten their recovery time.

J. Adv. Vet. Anim. Res., 8(3): 355-360, September 2021

http://doi.org/10.5455/javar.2021.h522

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Published

2021-07-02

How to Cite

Naef, H., Alhussen, M. A., Vatnikov, Y. A., Cheskidova, L. V., Semenova, V. I., Parshin, P. A., & Alsalh, M. A. (2021). Parameters of nonspecific resistance of calves with respiratory pathology before and after treatment. Journal of Advanced Veterinary and Animal Research, 8(3), 355–360. Retrieved from https://banglajol.info/index.php/JAVAR/article/view/76369

Issue

Vol. 8 No. 3 (2021)

Section

Original Articles

License

Copyright (c) 2021 Hamdan Naef, Mohammad Abed Alhussen, Yury Anatolyevich Vatnikov, Liliya Valeryevna Cheskidova, Valentina Ivanovna Semenova, Pavel Andreevich Parshin, Mohammad Almohammad Alsalh

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