Dietary supplementation of nano-selenium eliminates the negative effects of long-term ivermectin injection on growth and reproductive performance of female rabbits

Authors

  • Set A El Shobokshy Department of Nutrition and Veterinary Clinical Nutrition, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt.
  • Magda Ismail Abo-Samaha Poultry Breeding and Production, Department of Animal Husbandry and Animal Wealth Development, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt. https://orcid.org/0000-0002-0139-8781
  • Samia Mohamed Abd El Rheem Theriogenology Department, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt.
  • Ferial Mohamed Sahwan Animal Breeding and Production, Department of Animal Husbandry and Animal Wealth Development, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt.
  • Gemechu Wirtu Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, AL, USA.
  • Mosaad Abdel Khalek Soltan Department of Nutrition and Veterinary Clinical Nutrition, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt.
  • Mohamed Emam Department of Nutrition and Veterinary Clinical Nutrition, Damanhour University, Damanhour, Egypt.

Keywords:

Growth; ivermectin; nano-selenium; rabbit; reproduction

Abstract

Objective: We investigated the effects of a source of selenium [inorganic or nano-selenium (nano-Se)] on female V-line rabbits with or without injection of ivermectin (IVM). Material and Methods: Eighty-four rabbits (12 weeks old) were randomly divided into 4 groups of 21 rabbits each with the basal diet supplemented as per the following treatments: G1 (control): inorganic Se at 0.3 mg/kg diet with no IVM injection; G2: inorganic Se with IVM injection; G3: nano-Se with no IVM injection; and G4: nano-Se with IVM injection. IVM was injected subcutaneously at 0.2 mg/kg body weight starting when the does were 14 weeks old and repeated weekly for five consecutive weeks. Results: Replacement of inorganic Se with nano-Se improved body weight and total body weight gain, total feed intake, average feed conversion ratio, and reproductive performance (age at puberty, number of service/conceptions, conception rate, number of kits/litter, and litter weight at birth). Similarly, sexual activity of does, serum estrogen levels, and serum levels of antioxidants (glutathione reduced, catalase, and malondialdehyde) increased in nano-Se-supplemented groups. Ivermectin treatment in inorganic Se-supplemented groups was detrimental to growth and reproductive performance, while these parameters improved in IVM-treated and nano-Se-supplemented groups. Conclusion: Nano-Se mitigated the negative effects of IVM treatment on the growth and reproductive performance of does.

J. Adv. Vet. Anim. Res., 9(1): 128–137, March 2022

http://doi.org/10.5455/javar.2022.i577

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Published

2022-03-12

How to Cite

El Shobokshy, S. A., Abo-Samaha, M. I., Abd El Rheem, S. M., Sahwan, F. M., Wirtu, G., Soltan, M. A. K., & Emam, M. (2022). Dietary supplementation of nano-selenium eliminates the negative effects of long-term ivermectin injection on growth and reproductive performance of female rabbits. Journal of Advanced Veterinary and Animal Research, 9(1), 128–137. Retrieved from https://banglajol.info/index.php/JAVAR/article/view/79971

Issue

Vol. 9 No. 1 (2022)

Section

Original Articles

License

Copyright (c) 2022 Set A El-Shobokshy, Magda Ismail Abo-Samaha, Samia Mohamed Abd El-Rheem, Ferial Mohamed Sahwan, Gemechu Wirtu, Mosaad Abdel Khalek Soltan, Mohamed Emam

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