Effect of topical Areca palm L. hydroalcoholic extract on burn wound healing in rats

Authors

  • Zahra Abbasy Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
  • Abolfazl Azami Tameh Anatomical Sciences Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
  • Reza Mozaffari Kermani Department of Pathology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
  • Hamid Zaferani Arani Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
  • Sayyed Alireza Talaei Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.

Keywords:

Areca catechu; hydroalcoholic extract; burn wound; wound healing; rats

Abstract

Objectives: Wound healing is a complex and dynamic process that begins immediately following tissue injury and continues until the wound is completely healed and remodeled. Applying the most effective burn repair techniques is a constant challenge in medicine. Antiulcerogenic and wound healing properties of Areca palm leaves have been validated through various investiga­tions and animal studies. This study aimed to determine the potential for A. palm hydroalcoholic extract to heal burn wounds in rats.  Materials and Methods: For 14 days, we examined 40 male Wistar albino rats in 5 groups: those receiving 1% silver sulfadiazine cream (reference standard), those receiving eucerin (positive con­trol), and those receiving 5% and 10% ointments of Areca catechu hydroalcoholic extract (treat­ment groups). No treatment was given to the negative control group. On the dorsal part of the animals’ necks, burn wounds were made. After the rats were sacrificed, the wound contraction rate (WCR) was determined, and the wound sites were histopathologically examined.  Results: On the 14th day, the WCR was significantly higher in rats treated with A. palm 10% extract ointment than in rats treated with 5% extract, positive or negative control groups (p < 0.001), or rats treated with silver sulphfadiazine (p = 0.01). After applying a 10% extract ointment to burn wound sites, complete healing occurred with only mild tissue inflammation and edema.  Conclusion: The study’s findings indicate that the hydroalcoholic extract of A. palm L. has the abil­ity to expedite the wound healing process. Additional research is necessary to identify the com­pounds responsible for their wound healing properties and comprehend their action mechanism.

J. Adv. Vet. Anim. Res., 8(4): 619–628, December 2021

http://doi.org/10.5455/javar.2021.h553

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Published

2021-11-02

How to Cite

Abbasy, Z., Tameh, A. A., Kermani, R. M., Arani, H. Z., & Talaei, S. A. (2021). Effect of topical Areca palm L. hydroalcoholic extract on burn wound healing in rats. Journal of Advanced Veterinary and Animal Research, 8(4), 619–628. Retrieved from https://banglajol.info/index.php/JAVAR/article/view/79994

Issue

Vol. 8 No. 4 (2021)

Section

Original Articles

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Copyright (c) 2021 Zahra Abbasy, Abolfazl Azami Tameh, Reza Mozaffari Kermani, Hamid Zaferani Arani, Sayyed Alireza Talaei

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