Association between Plasma Homocysteine Level and Ischemic Stroke

Authors

  • A Rahman Registrar, Department of Neurology, Sir Salimullah Medical College Mitford Hospital, Dhaka
  • R Dasgupta Assistant Professor, Department of Nephrology, Dhaka Medical College, Dhaka
  • FA Quraishi Professor, Department of Neurology, National Institute of Neurosciences & Hospital, Dhaka
  • UK Saha Assistant Professor, Department ofNeurology, Sir Salimullah Medical College, Dhaka
  • Z Ali Assistant Professor, Department of Neurology, Sir Salimullah Medical College, Dhaka
  • S Hossain Professor, Department of Neurology, Sir Salimullah Medical College, Dhaka
  • MNA Miah Assistant Professor, Department of Medicine, Sir Salimullah Medical College, Dhaka Dhaka

DOI:

https://doi.org/10.3329/jbcps.v31i3.20978

Keywords:

Homocysteine, carotid artery stenosis, ischemic stroke

Abstract

Background: Epidemiologic studies have identified hyperhomocysteinemia as a possible risk factor for atherosclerosis. The aim of my study was based on evaluation of relationship between homocysteinemia with ischemic stroke patients.

Methods and materials: It was a prospective observational study conducted in the Department of Neurology, Sir Salimullah Medical College & Mitford hospital, Dhaka. Thirty six consecutive patients with ischemic stroke were analyzed by serum total homocysteine, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride and Equal number of controls same ages were compared with the case group.

Result: Mean Fasting blood sugar, serum fasting total cholesterol (TC), serum fasting Low density lipoprotein (LDL) were significantly higher in case group (p=0.001). Serum TC and LDL had a positive correlation with serum homocystine a (p=0.001). Serum High density lipoprotein (HDL) had a negative correlation (p=0.718) and serum triglyceride (TG) had a negative correlation (p = 0.182). Total plasma fasting homocysteine level in case group was 21.89 ± 9.38 ìmol/l and control group was 12.31 ± 3.27 ìmol/l, (p=0.001). Elevated fasting homocystein level was found in 75.0% of ischemic stroke patient and in 16.67% of healthy controls (p=0.001). The incidence of hyperhomocysteinemia is higher in ischaemic stroke cases than that in age-sex matched healthy controls.

Conclusion: Hyperhomocysteinemia is strongly associated ischaemic stroke patients. Hence it seems to be an important vascular risk factor in this study.

DOI: http://dx.doi.org/10.3329/jbcps.v31i3.20978

J Bangladesh Coll Phys Surg 2013; 31: 128-133

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Published

2014-11-27

How to Cite

Rahman, A., Dasgupta, R., Quraishi, F., Saha, U., Ali, Z., Hossain, S., & Miah, M. (2014). Association between Plasma Homocysteine Level and Ischemic Stroke. Journal of Bangladesh College of Physicians and Surgeons, 31(3), 128–133. https://doi.org/10.3329/jbcps.v31i3.20978

Issue

Vol. 31 No. 3 (2013)

Section

Original Articles

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