Clinical and Biochemical Characteristics and Aetiology of Asymptomatic Raised Alanine Aminotransferase in Newly Detected Diabetes and Impaired Glucose Tolerance Patients

Authors

  • Md Mahbubur Rahman Senior Medical Officer, Dept. of Gastroenterology, BIRDEM General Hospital, Dhaka
  • Md Golam Azam Junior Consultant, Dept. of Gastroenterology, BIRDEM General Hospital, Dhaka
  • Md Nowshad Ali Department of Gastroenterology, SSMC& Mitford Hospital, Dhaka
  • Mostafa Nur Mohsin Resident Physician, Sadar Hospital, Cox?s Bazar
  • Md Shah Jamal Junior Consultant (Medicine), 200 Bedded General Hospital, Narayangonj
  • Muhammad Abdur Rahim Registrar, Dept. of Medicine, BIRDEM General Hospital, Dhaka
  • Habib Ahmed Deputed at BIRDEM General Hospital, OSD, DGHS of Bangladesh
  • Md Nazmul Hoque Junior Consultant, Dept. of Gastroenterology, BIRDEM General Hospital, Dhaka
  • Tareq Mahmud Buiyan Associate Professor, Dept. of Gastroenterology, BIRDEM General Hospital, Dhaka
  • Md Anisur Rahman Professor, Dept. of Gastroenterology, BIRDEM General Hospital, Dhaka

DOI:

https://doi.org/10.3329/jbcps.v33i2.28022

Keywords:

alanine aminotransferase, asymptomatic, diabetes mellitus, impaired glucose tolerance, non-alcoholic fatty liver disease

Abstract

Objectives: Clinical evaluation and identification of aetiology of asymptomatic raised serum alanine aminotransferase (ALT) level in newly detected adult diabetic and impaired glucose tolerance (IGT) patients.

Methods: In this cross-sectional study, newly detected adult diabetic and IGT patients having asymptomatic raised serum ALT level of > 1.5 times of upper limit of normal were evaluated clinically and by laboratory tests.

Results: Total number of patients was 120, which was 3.1% of all newly registered diabetic and IGT patients over the study period. Male were 74 and female 46. Diabetes mellitus (DM) was found in 93.3% cases and IGT in 6.7%. Mean age was 43.1 years, mean body weight was 64.5 kg and mean body mass index (BMI) was 25.5 kg/m2. Central (abdominal) obesity was found in 61.5% cases. Increased waist hip ratio was found in 86.3% cases. Hypertension and hepatomegaly were present in 35% and 5.8% cases respectively. Dyslipidaemia was found in 98.3% cases and 45% patients fulfilled criteria for metabolic syndrome. Regarding etiology, 76.7% cases had non-alcoholic fatty liver disease (NAFLD), 8.3% had HBsAg sero-positivity, 4.2% had anti-HCV seropositivity and 3.3% had both NAFLD and HBsAg seropositivity. In 7.5% cases no cause was found. Raised serum ALT level had a significant correlation with metabolic syndrome (p= 0.016) and increasing age (p= 0.008).

Conclusion: Elevation of serum ALT is common in DM and IGT. NAFLD is the commonest cause followed by hepatitis B and C virus infection.

J Bangladesh Coll Phys Surg 2015; 33(2): 70-74

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Author Biography

Md Mahbubur Rahman, Senior Medical Officer, Dept. of Gastroenterology, BIRDEM General Hospital, Dhaka



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Published

2016-06-05

How to Cite

Rahman, M. M., Azam, M. G., Ali, M. N., Mohsin, M. N., Jamal, M. S., Rahim, M. A., Ahmed, H., Hoque, M. N., Buiyan, T. M., & Rahman, M. A. (2016). Clinical and Biochemical Characteristics and Aetiology of Asymptomatic Raised Alanine Aminotransferase in Newly Detected Diabetes and Impaired Glucose Tolerance Patients. Journal of Bangladesh College of Physicians and Surgeons, 33(2), 70–74. https://doi.org/10.3329/jbcps.v33i2.28022

Issue

Vol. 33 No. 2 (2015)

Section

Original Articles

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