Transient Acute Myeloid Leukemia in a Newborn with Down’s Syndrome

Authors

  • Zabrul SM Haque Professor of Neonatology, Ad-din Medical College Hospital, Dhaka
  • Nasim Jahan Assistant Professor of Neonatology, Addin Medical College Hospital, Dhaka
  • Biplob Kumar Raha Assistant Professor of Neonatology, Ad-din Medical College Hospital, Dhaka
  • Mahmuda Hassan Associate Professor of Neonatology, Ad-din Medical College Hospital, Dhaka
  • Mariam Begum Assistant Professor of Neonatology, Ad-din Medical College Hospital, Dhaka
  • AWS Rob Assistant Professor of Neonatology, Ad-din Medical College Hospital, Dhaka
  • Sabina Yasmin Indoor Medical Officer of Neonatology, Ad-din Medical College Hospital, Dhaka
  • SKA Hasnat Indoor Medical Officer of Neonatology, Ad-din Medical College Hospital, Dhaka
  • Tasnim Farhana Indoor Medical Officer of Neonatology, Ad-din Medical College Hospital, Dhaka

DOI:

https://doi.org/10.3329/jbcps.v34i4.32489

Keywords:

Down's syndrome, Transient myeloproliferative disease, Transient leukemia

Abstract

We report the case of a newborn with Down's syndrome associated with transient acute myeloid leukemia (AML). The leukemic presentation resolved spontaneously without treatment just 4 weeks after birth. A 2 days old newborn presented with respiratory distress, lethargy, poor suck and mild hepatosplenomegaly with features of Down's syndrome. Total white cell count was 144,000/cmm with blasts 92%. Other Septic work up was negative. Peripheral blood smear revealed hyper leukocytosis and presence of blast cells. Flow cytometric analysis revealed acute myeloid leukemia. The peripheral blast cells persisted for 4 weeks, after which the hemogram and the differential WBC count returned to normal and a final diagnosis of transient acute myeloid leukemia was made. Only few cases of congenital leukemia with Down's syndrome have been reported in the literature. In Down's syndrome, AML whether transient or not, generally shows cytogenetic and molecular aspects that differ from those of adult acute leukemias

J Bangladesh Coll Phys Surg 2016; 34(4): 213-217

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Author Biography

Zabrul SM Haque, Professor of Neonatology, Ad-din Medical College Hospital, Dhaka



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Published

2017-05-07

How to Cite

Haque, Z. S., Jahan, N., Raha, B. K., Hassan, M., Begum, M., Rob, A., Yasmin, S., Hasnat, S., & Farhana, T. (2017). Transient Acute Myeloid Leukemia in a Newborn with Down’s Syndrome. Journal of Bangladesh College of Physicians and Surgeons, 34(4), 213–217. https://doi.org/10.3329/jbcps.v34i4.32489

Issue

Section

Case Reports