Comparative Study of Evaluation of Efficacy and Safety of Combination of Erythromycin and Benzyl Peroxide with Benzyl Peroxide alone in the Treatment of Acne Vulgaris

Authors

  • Monira Yeasmin Associate Professor, Department of Dermatology and Venereology, Anwer Khan Modern Medical College, Dhaka
  • AZM Maidul Islam Head of the Department, Department of Dermatology and Venereology, Anwer Khan Modern Medical College, Dhaka

DOI:

https://doi.org/10.3329/jbcps.v35i4.34737

Keywords:

Acne, Benzyl peroxide, Erythromycin

Abstract

Objective: Acne vulgaris is the disease of the teenagers as 90% of them being affected. So many treatment modalities are there - systemic , topical and physical . Among them topical therapy is the main stay of treatment. Our study was to determine the efficacy and safety of combination of erythromycin/benzyl peroxide compared with benzyl peroxide alone in the treatment of mild to moderate acne.

Method: Patients attended in a Charity Foundation were enrolled for the study after fulfilling the criteria. Among total 50 patients 25 were selected for group A and another 25 for group B.. Group A were treated with 3% erythromycin and 5% Benzyl peroxide combination and GroupB with 5% Benzyl peroxide only. Total acne lesions were counted at base line and after 4 , 8 and 12 weeks of follow up. Reduction of total no of lesions were seen and analyzed.

Result: At baseline mean of total acne score was 33.60 ± 5.98 and 33.53 ± 5.68 in group A and B (p=0.965). After 12 week it was 2.27 ± 1.08 and 6.27 ± 1.57 respectively in group A and B (p=0.001). Percent reduction of acne severity from base line to final follow up was 93.24 ± 3.11 in group A and 81.17 ± 4.22 in group B (p=0.001). So we can see better reduction of lesion count in Group A than Group B.

Conclusion: We conclude that Group A is safer and more effective than that of Group B. So the combination of Benzyl peroxide and erythromycin is better than Benzyl peroxide alone.

J Bangladesh Coll Phys Surg 2017; 35(4): 174-178

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Published

2017-11-30

How to Cite

Yeasmin, M., & Islam, A. M. (2017). Comparative Study of Evaluation of Efficacy and Safety of Combination of Erythromycin and Benzyl Peroxide with Benzyl Peroxide alone in the Treatment of Acne Vulgaris. Journal of Bangladesh College of Physicians and Surgeons, 35(4), 174–178. https://doi.org/10.3329/jbcps.v35i4.34737

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Section

Original Articles