Efficacy of Intravenous Immunoglobulin in the Management of Guillain Barre Syndrome
Keywords:Intravenous Ig, Guillain barre syndrome
A total number of 40 respondents consisting of 20 subjects
of Guillain barre syndrome in each group treated with
intravenous immunoglobulin (case) and without IVIg were
selected during the study period. Out of 20 cases, 12 (60%)
were male and 8 (40%) were females, ratio 1.5:1. Majority
of the cases were presented at second or third decade of
life. In control group, 11 (55%) were male and 9 (45%)
female, ratio 1.22:1. Majority of the patients had history of
upper respiratory tract infection or acute gastroenteritis 1
4 weeks preceding illness. All the patients had flaccid
paralysis in all four limbs with some sensory features without
bowel and bladder involvement. Thirteen patients from the
case and control groups developed respiratory failure requiring
ICU support. Cerebrospinal fluid study showed
albumin cytological dissociation. Nerve conduction study
showed features of demyelination, axonal loss or both.
There was significant improvement of GBS patients
treated with IVIg in respect of respiratory function,
muscle tone, muscle power, jerks and autonomic
function. ICU stay of patients treated with IVIg was
significantly shorter. Final outcome of patients treated
with IVIg showed one death. There was no death in
control group. The patient died probably due to severity
of disease and/or comorbid disease.
Key words: Intravenous Ig; Guillain barre syndrome
J Bangladesh Coll Phys Surg 2010; 28: 81-85
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