Are Oral Hypoglycemic Agents Contraindicated in Pregnancy!
AbstractThe incidence of gestational diabetes is increasing. There
has been a traditional reluctance to recommend oral
antidiabetic drugs for the management of hyperglycaemia
in gestational diabetes mellitus The medical management
of gestational diabetes is still evolving, and recent
randomized controlled trials have given a glimse of hope
for woman who likes to avoid insulin and prefer oral agents..
As insulin therapy is considered the gold standard of
pharmacotherapy for gestational diabetes, it becomes a
usual recommendation to use it in pregnanacy. The current
short acting insulin analogs lispro and aspart are safe, but
there are only limited data to support the use of long acting
insulin analogs. There are randomized controlled trials
which have demonstrated efficacy of the oral agents
glyburide and metformin. Whilst short-term data have not
demonstrated adverse effects of glyburide and metformin
on the fetus, and they are increasingly being used in
pregnancy, there remain long-term concerns regarding their
potential for harm. This controversy related article gives
an overview of the rationale for use of oral antidiabetic
agents in the treatment of gestational diabetes.
J Bangladesh Coll Phys Surg 2010; 28: 129-131
How to Cite
Submission of a manuscript for publication implies the transfer of the copyright from the author to the publisher upon acceptance. Accepted manuscripts become the permanent property of the Journal of Bangladesh College of Physicians and Surgeons and may not be reproduced by any means in whole or in part without the written consent of the publisher.
No part of the materials published in this journal may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the publisher. Reprints of any article in the Journal will be available from the publisher.