Disease Severity and Clinical Outcome of Coronavirus Vaccinated Patients Following Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection

Authors

  • Nirmal Kanti Sarkar Assistant Professor, Department of Respiratory Medicine, National Institute of Diseases of the Chest and Hospital, Dhaka, Bangladesh
  • Moumita Roy Junior Consultant, Department of Obstetrics & Gynecology, Deputed - Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Salahuddin Feroz Junior Consultant, Department of Nephrology, Sheikh Hasina National Institute of Burn and Plastic Surgery, Dhaka, Bangladesh
  • Md Ashadur Rahman Senior Consultant (former), Department of Respiratory Medicine, 250-Bedded T.B Hospital, Shyamoli, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/jbcps.v41i4.68928

Keywords:

Coronavirus vaccine, COVID-19, SARS-CoV-2

Abstract

Background and aims: The severity of illness and mortality in coronavirus disease (COVID-19) may be curtailed byvaccination. We assessed the disease severity and clinical outcome in coronavirus vaccinated patients following SARSCoV-2 infection.

Methods: We conducted an observational study among theSARS-CoV-2 infected patients who received one or two doses of a single generic type of coronavirus vaccine (ChAdOx1nCoV-19, Covishield®, Serum Institute of India) at the outset of vaccine rollout program in Bangladesh. Eligible patients treated at home, outpatient basis, or hospitalized between April 10, 2021, and June 18, 2021, were included. Demographic characteristics, clinical presentation, comorbidities, radiological features, disease severity, treatment protocol, and outcomes were evaluated. The primary end point was disease severity (mild, moderate, severe, and critical).The secondary endpoint was clinical outcome (complete recovery or death) at day 28.

Results: The cohort included total 61 patients. Age ranged between 23–82 year; majority were male (62.3%). Ninety-five percent patients received a single dose of vaccine. Most of the patients had mild symptoms (63.9%), and treated at home (67.2%). Most of the patients recovered utterly (95.1%) without any death. Vaccination showed reduced disease severity (RR 0.93, 95% CI, 0.87-0.99).

Conclusions: In this study it was observed that coronavirus vaccine may significantly lessen disease severity, improve clinical outcome, and prevent death among SARS-CoV-2infected patients.

J Bangladesh Coll Phys Surg 2023; 41(4): 294-297

 

Downloads

Download data is not yet available.
Abstract
2
PDF
2

Downloads

Published

2023-10-26

How to Cite

Sarkar, N. K. ., Roy, M. ., Feroz, S. ., & Rahman, M. A. . (2023). Disease Severity and Clinical Outcome of Coronavirus Vaccinated Patients Following Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. Journal of Bangladesh College of Physicians and Surgeons, 41(4), 294–297. https://doi.org/10.3329/jbcps.v41i4.68928

Issue

Vol. 41 No. 4 (2023)

Section

Original Articles

License

Submission of a manuscript for publication implies the transfer of the copyright from the author to the publisher upon acceptance. Accepted manuscripts become the permanent property of the Journal of Bangladesh College of Physicians and Surgeons and may not be reproduced by any means in whole or in part without the written consent of the publisher.

No part of the materials published in this journal may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the publisher. Reprints of any article in the Journal will be available from the publisher.