First Ever Pediatric Allogeneic Hematopoietic Stem Cell Transplantation In A Transfusion Dependent Thalassemia Patient In Bangladesh- A Case Report With 17 Months Post-Transplant Follow Up

Authors

  • Shormin Ara Ferdousi Professor, Child Specialist and Pediatric Oncologist, Gonoshasthaya Nagor Hospital and Shomaj vittik Medical College, Dhaka, Bangladesh
  • Mir Hasan Md Moslem Associate Professor, Combined Military Hospital, Barishal, Bangladesh
  • Kamrun Nahar Associate Professor, Pediatric Hematology and Oncology, Combined Military Hospital, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/jbcps.v43i1.78794

Keywords:

Hematopoietic, Thalassemia

Abstract

Background: Hematopoietic stem cell transplantation (HSCT) is the mainstay of treatment for many disease conditions. The first allogeneic HSCT was done by E. Donnall Thomas which was reported in the New England Journal of Medicine in September 1957. In that study six patients of Acute Leukemia were treated with radiation and chemotherapy followed by intravenous infusion of marrow from a normal donor where only two patients were engrafted but all died within 100 days of transplantation. In 1979 Thomas applied allogeneic HSCT earlier in the course of acute leukemia and reported a 50% cure rate in AML patients transplanted after first remission. In Bangladesh there was no scope of HSCT for thalassemia patients. The first ever pediatric allogeneic HSCT in a transfusion dependent thalassemia patient was performed in BMT center of CMH Dhaka on 30 November 2021. Here the case is reported with 17 months post-transplant follow up. Case Report: Arfin a 3 years 11 months old boy first reported in November 2018 with the history of repeated blood transfusion since 6 months of age and was diagnosed as a case of Hb-E Beta thalassemia. On initial presentation he had hepatomegaly, splenomegaly, stunting, high serum ferritin level, and high liver iron concentration and was treated with regular irradiated and filtered PRBC with multiple iron chelating agents. On 30 November 2021 allogeneic HSCT of that patient was successfully completed. Donor was his elder brother who was Hb-E trait and had 10/10 HLA full matches. In April 2023 after 17 months during post-transplant follow up his Hb was 10.3 gm/dl, serum ferritin level was normal, had normal growth and required no further blood transfusion after transplantation. Conclusion: In transfusion dependent thalassemia patients allogeneic HSCT is curative. This is the first and successful case of allogeneic HSCT in thalassemia patients in Bangladesh.

J Bangladesh Coll Phys Surg 2025; 43: 77-80

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Published

2025-01-30

How to Cite

Ferdousi, S. A., Moslem, M. H. M., & Nahar, K. (2025). First Ever Pediatric Allogeneic Hematopoietic Stem Cell Transplantation In A Transfusion Dependent Thalassemia Patient In Bangladesh- A Case Report With 17 Months Post-Transplant Follow Up. Journal of Bangladesh College of Physicians and Surgeons, 43(1), 77–80. https://doi.org/10.3329/jbcps.v43i1.78794

Issue

Vol. 43 No. 1 (2025)

Section

Case Reports

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