Efficacy of Mantoux Test in Detecting Latent Tubercular Infection in Nephrotic Children

Authors

  • Shabnam Sharmin Assistant Professor, Department of Pediatric Nephrology, Shaheed Suhrawardy Medical College, Dhaka, Bangladesh
  • Ishrat Jahan Ima Senior Instructor, Shishu Bikas Kendro HSM, DGHS, Bangladesh
  • Md Shafiul Alam Assistant Professor, Paediatric Gastroenterology & Nutrition, Shaheed Suhrawardy Medical College, Dhaka, Bangladesh
  • Shamsi Sumaiya Ashique Assistant Professor Department of Pediatrics, National Centre for Control of Rheumatic Fever and Heart disease, Dhaka, Bangladesh
  • MT Anjumanara Khatun Assistant Registrar of pediatrics, Paediatric Nephrology, NIKDU, Dhaka, Bangladesh
  • Md Reaz Uddin Assistant Professor, Paediatric Nephrology, NIKDU, Dhaka, Bangladesh
  • Md Kabir Alam Associate Professor (Current charge) Department of Pediatric Nephrology NIKDU, Dhaka, Bangladesh
  • Mohammed Anwar Hossain Khan Ex-Prof & Head of the Department of Pediatric Nephrology NIKDU, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/jbcps.v43i1.78983

Keywords:

Nephrotic Syndrome, Latent Tuberculosis infection, Quanti FERON-TB Gold Plus Test, Mantoux Test

Abstract

Background: Nephrotic syndrome (NS) is the most common kidney disease in children. These children are immunocompromised and very prone to infections like tuberculosis (TB) that can flare up during treatment. Latent tuberculosis (LTB) infection is not uncommon in nephrotic children and is difficult to diagnose, particularly due to the overestimation of the Mantoux Test (MT). The study aimed to analyze the ability of Mantoux test in detecting LTBI in nephrotic children. Methods: This cross-sectional analytic study was conducted at the Department of Pediatric Nephrology of National Institute of Kidney Disease and Urology (NIKDU), Dhaka, Bangladesh from October 2019 to March 2021. A total of 91 BCG vaccinated nephrotic children aged 1-12 year were included in this study through convenient sampling using specific inclusion and exclusion criteria. Statistical analysis was done by using SPSS 23. Qualitative data were compared by chi-square test and quantitative data were compared by ttest. Results: Considering the QuantiFERON TB Gold Plus test as reference the MT test showed 100% sensitivity, 75.9% specificity, 28.57% positive predictive value, 100% negative predictive value, and 78.02% accuracy. Conclusion: Latent TB must be confirmed by QFT- plus test before giving treatment of nephrotic syndrome.

J Bangladesh Coll Phys Surg 2025; 43: 20-24

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Published

2025-01-30

How to Cite

Sharmin, S., Ima, I. J., Alam, M. S., Ashique, S. S., Khatun, M. A., Uddin, M. R., … Khan, M. A. H. (2025). Efficacy of Mantoux Test in Detecting Latent Tubercular Infection in Nephrotic Children. Journal of Bangladesh College of Physicians and Surgeons, 43(1), 20–24. https://doi.org/10.3329/jbcps.v43i1.78983

Issue

Vol. 43 No. 1 (2025)

Section

Original Articles

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