Pediatric Onset Myelin Oligodendrocyte Glycoprotein-Associated Disease: A Series of Four Cases

Authors

  • Paramita Barua FCPS part 2 Trainee, Department of Pediatric Neurology, Bangladesh Medical University, Dhaka, Bangladesh https://orcid.org/0009-0004-5402-5761
  • Rabeya Tasnim MD Phase B Resident, Department of Pediatric Neurology, Bangladesh Medical University, Dhaka, Bangladesh
  • Munmun Sultana Anny Medical Officer, Pediatric Neurology, Bangladesh Medical University, Dhaka, Bangladesh
  • Kanij Fatema Professor, Department of Pediatric Neurology, Bangladesh Medical University, Dhaka, Bangladesh https://orcid.org/0000-0002-2465-053X

Keywords:

children, myelin-oligodendrocyte glycoprotein, myelin oligodendrocyte glycoprotein antibody-associated disease.

Abstract

Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOG-AD) is a rare inflammatory demyelinating disease of the central nervous system with monophasic and relapsing manifestations. The most common presenting phenotypes of MOG-AD in pediatric population include acute disseminated encephalomyelitis (ADEM), optic neuritis (ON), transverse myelitis (TM) and brainstem syndromes. Here, we report four cases of MOG-AD in pediatric patients. Patients presented with headache, gait disorder, dysarthria, seizure. The first case had weakness of both lower limbs with irritability, 2nd case had altered conscious level with seizure along with walking and   speech difficulty. The 3rd case had relapsing features, visual and speech problem with optic neuritis after 2 years of treatment. The 4th case had headache and unsteady gait, visual impairment and speech difficulty.  Most of the patients had demyelinating features in magnetic resonance imaging (MRI) of brain.  All the four cases were positive for anti-MOG antibody. Treatment was done according to the protocol of the institute with steroid, intravenous immunoglobulin and rituximab.

J Bangladesh Coll Phys Surg 2026; 44: 198-203

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Published

2026-07-30

How to Cite

Barua, P., Tasnim, R., Anny, M. S., & Fatema, K. (2026). Pediatric Onset Myelin Oligodendrocyte Glycoprotein-Associated Disease: A Series of Four Cases. Journal of Bangladesh College of Physicians and Surgeons, 44(3), 198-203. https://doi.org/10.3329/jbcps.v44i3.91555

Issue

Vol. 44 No. 3 (2026)

Section

Case Reports

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How to Cite

Barua, P., Tasnim, R., Anny, M. S., & Fatema, K. (2026). Pediatric Onset Myelin Oligodendrocyte Glycoprotein-Associated Disease: A Series of Four Cases. Journal of Bangladesh College of Physicians and Surgeons, 44(3), 198-203. https://doi.org/10.3329/jbcps.v44i3.91555