Implications of mpMRI Guided Targeted Biopsy for Diagnosis of Prostate Cancer: Experience in a Military Hospital of Bangladesh
Keywords:
Prostate cancer, PSA, mpMRI, Systematic biopsy, Targeted biopsy.Abstract
Background: Targeted prostate biopsy (TGBx) has become widely adopted technique, driven by advances in multiparametric magnetic resonance imaging (mpMRI). Unlike systematic biopsy (SBx), which samples the prostate in a uniform, non-specific manner, TGBx directs biopsy cores to suspicious lesions identified on mpMRI, potentially enhancing detection of clinically significant disease. Several studies have reported superior diagnostic yield with TGBx compared to SBx. Against this backdrop this study has been designed to evaluate and compare the prostate cancer detection rates of SBx and TGBx in biopsy-naive men in Bangladesh.
Methods: A cross-sectional study was conducted in the Department of Urology, CMH Dhaka, from July 2022 to June 2023. Total 178 men have been enrolled aging 41–80 years with serum PSA >4 ng/ml and/or abnormal digital rectal examination findings, and with a Prostate Imaging Reporting and Data System (PI-RADS) score ≥3.
Results: Out of 178 study population, the overall cancer detection rate (CDR) was 53.4% (95/178). Both total and clinically significant (CS) prostate cancer detection rates were higher in patients who underwent mpMRI compared with those who did not. The CDR was higher in the targeted group than in the systematic group (55.81% vs. 48.15% respectively, p > 0.05). Again, targeted biopsy was superior than systematic biopsy in the detection rate of CS PCa patients, though the difference was not statistically significant (48.8% vs. 40.7%, respectively, p = 0.732). The clinically insignificant (CI) PCa detection rate was almost similar between the two groups (6.98% vs. 7.41%, p > 0.05).
Conclusion: Pre-biopsy mpMRI with targeted sampling improves prostate cancer detection compared with systematic biopsy and may contribute better diagnostic accuracy in our country.
J Bangladesh Coll Phys Surg 2026; 44: 169-175
9
9
Downloads
Published
How to Cite
Issue
Section
License
Submission of a manuscript for publication implies the transfer of the copyright from the author to the publisher upon acceptance. Accepted manuscripts become the permanent property of the Journal of Bangladesh College of Physicians and Surgeons and may not be reproduced by any means in whole or in part without the written consent of the publisher.
No part of the materials published in this journal may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the publisher. Reprints of any article in the Journal will be available from the publisher.
