Clinicopathological profile and receptor status in recurrent breast carcinoma
Keywords:
Recurrent breast cancer; Triple-negative breast cancer (TNBC); Hormone receptor status; HER2 receptor; Immunohistochemistry (IHC)Abstract
Background: Breast carcinoma is one of the most common malignancies worldwide, with approximately one million new cases diagnosed annually. Estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2) play a crucial role in determining prognosis and guiding treatment strategies.
Objective: To assess the demographics, site and TNM staging (pathology} and the ER, PR, and HER-2 reactivity patterns in recurrent breast carcinoma.
Methods: This cross-sectional study was conducted in the Department of Surgical Oncology, National Institute of Cancer Research & Hospital, Dhaka, from March 2022 to February 2023. Ninety histologically confirmed breast carcinoma patients who underwent either breast-conserving surgery or mastectomy with axillary dissection were included. ER, PR, and HER-2 receptor statuses were assessed by immunohistochemistry. Data were analyzed using SPSS version 26, with significance set at p<0.05.
Results: The mean age of patients was 46.7 ± 11.4 years; 53.3% were above 45 years. Among 44 triple-negative cases, 65.9% were below 45 years, while 90% of triple-positive cases were above 45 years (p=0.01). Most patients were multiparous (88.9%). Local recurrence occurred in 54.4% of cases, regional in 32.2%, and distant in 13.3%. ER positivity was found in 51.1%, PR positivity in 41.1%, and HER-2 negativity in 88.9%. Triple-negative breast cancer (TNBC) accounted for 48.9% of cases.
Conclusion: TNBC was found more in younger age and higher number of cases. Incomplete radiotherapy or chemotherapy contributed to recurrence. Tumor size is a prognostic factor, warranting aggressive adjuvant therapy to improve outcomes in TNBC patients.
J Bangladesh Coll Phys Surg 2026; 44: 182-188
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