Hba1c Variability Has a Strong Relationship With Peripheral Sensory And Motor Neuropathy in Type-2 Diabetes Mellitus

Authors

  • MA Hossain Plant Biotechnology and Genetic Engineering Lab., Institute of Biological Sciences, University of Rajshahi, Bangladesh
  • MK Sarkar Department of Neurology, Rajshahi Medical College, Rajshahi, Bangladesh
  • I Mahbub Department of Endocrinology, Sheikh Hashina National Institute of Burn and Plastic Surgery, Dhaka, Bangladesh
  • SMS Islam Plant Biotechnology and Genetic Engineering Lab., Institute of Biological Sciences, University of Rajshahi, Bangladesh

DOI:

https://doi.org/10.3329/jbs.v29i0.54825

Keywords:

Diabetic peripheral neuropathy, HbA1c, Motor neuropathy, Sensory neuropathy, Type-2 diabetes

Abstract

Diabetic peripheral neuropathy (DPN) is one of the most common long-term microvascular complications of diabetes. This study was undertaken to investigate the association of HbA1c variability with diabetic peripheral neuropathy (sensory and motor) in patients with type-2 diabetes. In this study, a total of 150 type-2 diabetic patients were screened for DPN and undergone quarterly HbA1c measurements during the year preceding enrolment were recruited. DPN was confirmed in patients displaying both clinical manifestations of neuropathy and neurological abnormalities assessment. Among the recruited patients, 24% were found to have DPN (sensory and motor), and these patients also presented with a higher HbA1c as compared to the patients without DPN (p<0.05). In addition, the advanced age and longer duration of diabetes were important and significant (p<0.05) risk factors for peripheral neuropathy. Overall study suggests that increased HbA1c level is strongly associated with DPN (sensory and motor) in type-2 diabetic patients and could be considered as a potent indicator for DPN in the recruited patients.

J. Bio-Sci. 29(1): 93-100, 2021 (June)

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Published

2021-07-11

How to Cite

Hossain, M. ., Sarkar, M. ., Mahbub, I., & Islam, S. . (2021). Hba1c Variability Has a Strong Relationship With Peripheral Sensory And Motor Neuropathy in Type-2 Diabetes Mellitus. Journal of Bio-Science, 29, 93–100. https://doi.org/10.3329/jbs.v29i0.54825

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