Impact of Insulin, Biguanide and Sulfonylurea Treatment on hba1c in Diabetic Patients: An Interventional Study in Rajshahi, Bangladesh

Abstract

Proper management and selection of a single drug or multiple drugs for the treatment of diabetes is very important. The choice of treatment depends on a number of factors. With the proper treatment, the state of diabetes can be managed very smoothly. The main objective of this study was to compare the efficacy of insulin, biguanides and sulfonylurea on HbA1C in diabetic patients. This interventional type of study was carried out among 102 diabetic patients attending at different hospitals in Rajshahi of Bangladesh. In this case purposive sampling technique was followed and data revealed that mean age of the patients was 45.98±11.23 years and most of them (35.30) were housewife. Among the insulin receiving group, 41.18% were male and 58.82% were female. In case of the biguanide receiving taking group 44.12% were male and 55.88% were female while for the sulfonylurea receiving group 35.29% were male and 64.71% were female. Regarding body mass index (BMI) among the respondents, it was found that 0.98% had BMI <18.50 kg/m2, led sedentary lifestyle (65.7%), most of them were from urban area (67.6%) and non-smoker (86.0%) with family history of type 2 diabetes mellitus (T2DM) (17.0%). In the insulin receiving group, 82.35% had desired glycemic control; in the biguanide receiving group, 73.53% had desired glycemic control; and in the sulfonylurea receiving group, 64.71% had desired glycemic control. Data shows that the insulin receiving patients had relatively better glycemic control as compared to the other two mendicant receiving groups at 6th month. This finding suggests that the selection of the best drug is the most key part of the treatment of T2DM. Therefore, this study would help to select the best choice of drug for the treatment of diabetes in Bangladesh.

J Bio-Sci. 30(1): 123-130, 2022 (June)