A Study of Evaluation of Serum Uric Acid Level in Obesity

Authors

  • Mosammat Tanjina Akther Consultant of Clinical Biochemistry, Epic Health Care, Chattogram.
  • Md Hafizul Islam Professor of Biochemistry, Chittagong Medical College, Chattogram.
  • Shammi Akter Lecturer of Biochemistry, Chittagong Medical College, Chattogram.
  • S M Zahed Kamal Registrar of Paediatrics, BGC Trust Medical College Hospital, Chattogram.
  • Hafsa Hasina Lecturer of Biochemistry, Chittagong Medical College, Chattogram.
  • Parvin Aktar Lecturer of Biochemistry, Chittagong Medical College, Chattogram.
  • Mahmudul Haque Professor and Senior Consultant of Biochemistry, Evercare Hospital, Chattogram.

DOI:

https://doi.org/10.3329/jcmcta.v33i2.67304

Keywords:

BMI; Hyperuricemia; Obesity; Waist circumference.

Abstract

Background: Obesity is rapidly increasing worldwide. High serum uric acid has been documented to be associated with obesity. Previous studies have shown a relationship between hyperuricemia and obesity but evidence of such an association in population of Bangladesh is limited. Recent study has been shown that hyperuricemia is a predictor of non-communicable diseases and increase in mortality rate. The aim of this study was to observe the association of serum uric acid with obesity.

Materials and methods: This cross-sectional study was carried out in the Department of Biochemistry in Chittagong Medical College and Outpatient Department of Endocrinology, Chittagong Medical College Hospital. One hundred and fifty (150) subjects ageing (18-55) years were included in this study by non-probability convenient sampling method. One hundred (100) subjects with obesity diagnosed by BMI enrolled as cases and fifty (50) normal weight were enrolled as controls. Important variables in this study were serum uric acid level, Fasting Lipid Profile, Fasting Plasma Glucose, Blood Pressure, BMI and Waist Circumference.

Results: Hyperuricemia was found 45% among cases (c2, p< 0.001) and 8% in controls. Serum Triglyceride (TG), Total Cholesterol, Increased BMI, waist circumference were positively associated with obesity and Hyperuricemia. There was also positive correlation between serum uric acid with TG, TC, LDL-cholesterol, BMI and waist circumference and negative correlation between serum uric acid with fasting blood glucose and HDL-cholesterol. However this study did not find any significant association between serum uric acid with LDL and HDL cholesterol.

Conclusion: The above mentioned findings suggest that, evaluation of serum uric acid level in obesity may provide data useful for the clinical course of diseases and further relevant research.

JCMCTA 2022 ; 33 (2) : 89-94

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Published

2022-12-31

How to Cite

Akther, M. T. ., Islam, M. H. ., Akter, S. ., Kamal, S. M. Z. ., Hasina, H., Aktar, P. ., & Haque, M. . (2022). A Study of Evaluation of Serum Uric Acid Level in Obesity. Journal of Chittagong Medical College Teachers&#039; Association, 33(2), 89–94. https://doi.org/10.3329/jcmcta.v33i2.67304

Issue

Section

Papers and Originals