Presentation and Outcomes of the Covid- 19 Among the Vaccinated and Nonvaccinated Patients

Authors

  • Mohammad Mostafa Kamal Assistant Professor (Medicine), MD (Neurology), Department of Medicine, Dhaka Medical College, Dhaka, Bangladesh
  • Ponkaj Kanti Datta Assistant Professor, Department of Medicine, Dhaka Medical College, Dhaka, Bangladesh
  • Mohmmad Mahfuzul Hoque Assistant Professor, Department of Medicine Dhaka Medical College, Dhaka
  • Muhammad Faizur Rahman Assistant Professor, Department of Medicine Dhaka Medical College, Dhaka
  • Mohammed Masudul Hassan Khan Assistant Professor, Department of Medicine Dhaka Medical College, Dhaka
  • Kamalesh Chandra Basu Assistant Professor, Department of Medicine Dhaka Medical College, Dhaka
  • Farazana Rahman Assistant Professor, Department of Medicine Dhaka Medical College, Dhaka
  • Mohammad Jahidul Hasan Assistant Professor (Medicine), Sir Salimullah Medical College and Mitford Hospital, Dhaka, Bangladesh
  • Reaz Mahmud Assistant Professor, Department of Neurology, Dhaka Medical College, Dhaka, Bangladesh
  • Rashedul Hassan Associate Professor, Green Life Medical College, Dhaka, Bangladesh
  • Morshed Md Moniruzzaman Assistant professor, Dept. of paediatrics. Shaheed M. Monsur Ali Medical College, Sirajgonj. Dhaka, Bangladesh
  • Taslima Aktar Consultant, Islami Bank Hospital, Mugda, Dhaka, Bangladesh
  • Md Shohidul Islam Junior Consultant (Medicine), Sarkari karmachari Hospital, Dhaka, Bangladesh
  • Israt Jahan Junior Consultant (Medicine), Sarkari karmachari Hospital, Dhaka, Bangladesh
  • SK Jakaria Been Sayeed Medical Officer, National Institute of Neurosciences and Hospital, Dhaka
  • Sanzida Akter Junior consultant (Neurology), BIRDEM General Hospital, Dhaka, Bangladesh
  • Liton Kumar Roy Junior consultant (Medicine), upazilla health complex, Kalihati, Tangail, Bangladesh
  • Md Titu Miah Professor, Department of Medicine, Dhaka Medical College, Dhaka, Bangladesh
  • Md Mujibur Rahman Professor, Department of Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/jdmc.v31i1.65488

Keywords:

COVID-19, second surge, vaccination program, previously infected, immune system, new variant of COVID-19

Abstract

Background: Previous infection or vaccination boosts up the body’s immune system. It may have a protective effect or an exaggerated immune response. Knowledge about the impact of vaccination or previous infection on the presentation and outcome of the new variant of COVID- 19 is scarce.

Objectives: In this study, vaccine effectiveness, reinfection rate and severity prediction among vaccinated and non-vaccinated COVID-19 infected patients were assessed.

Methods: This observational study was conducted in the COVID-19 unit of Dhaka Medical College Hospital. Three hundred forty-four patients who presented in the triage and were admitted to DMCH were enrolled as per inclusion criteria and were followed up for three months for outcome variables. Patients were divided into four groups by vaccination and previous infection. Results: Mortality was 18(14.6%), 10(14.3%), 14(22.6%), and 40(44.9%) in new COVID-19 in vaccinated, reinfection in vaccinated, new COVID-19 infection in unvaccinated, and reinfection in unvaccinated patients respectively. 5 (4.1%) of the newly infected vaccinated and 4 (6.5%) freshly infected unvaccinated, 14 (15.7%) reinfected unvaccinated patients were transferred to ICU for mechanical ventilation. The mean duration of the hospital stay was significantly (p<0.05) lower among the vaccinated group than in non-vaccinated patients.

Conclusion: This study suggests that vaccination of previously infected people may be associated with reducing the adverse outcome of COVID-19 infection.

J Dhaka Med Coll. 2022; 31(1) : 137-147

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Published

2023-05-03

How to Cite

Kamal, M. M. ., Datta, P. K. ., Hoque, M. M. ., Rahman, M. F. ., Khan, M. M. H. ., Basu, K. C. ., Rahman, F. ., Hasan, M. J. ., Mahmud, R. ., Hassan, R. ., Moniruzzaman, M. M., Aktar, T. ., Islam, M. S. ., Jahan, I. ., Sayeed, S. J. B. ., Akter, S. ., Roy, L. K. ., Miah, M. T. ., & Rahman, M. M. . (2023). Presentation and Outcomes of the Covid- 19 Among the Vaccinated and Nonvaccinated Patients. Journal of Dhaka Medical College, 31(1), 137–147. https://doi.org/10.3329/jdmc.v31i1.65488

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Section

Original Articles