A Case of C-ANCA Associated Vasculitis Presenting With Localised Skin Thickening

Authors

  • Md Ali Akbar Khan Department of Medicine, Dhaka Medical College Hospital, Dhaka, Bangladesh
  • Md Titu Miah Department of Medicine, Dhaka Medical College Hospital, Dhaka, Bangladesh
  • Sharar Naiarin Haque Department of Medicine, Dhaka Medical College Hospital, Dhaka, Bangladesh
  • Shah Mubdi Un Naafi Upazila Health Complex, Gangachara, Rangpur, Bangladesh
  • Sakib Abrar Upazila Health Complex, Daudkandi, Cumilla, Bangladesh

DOI:

https://doi.org/10.3329/jdmc.v31i1.65490

Keywords:

Vasculitis, ANCA-associated vasculitis, Response to treatment

Abstract

ANCA vasculitis, caused by antibodies named ANCA (anti-neutrophilic cytoplasmic autoantibodies), is an autoimmune disorder affecting small blood vessels of the body. Among p-ANCA and c- ANCA, c-ANCA (cytoplasmic ANCA) usually targets proteinase three inside neutrophils, causing inflammation of blood vessels. Herein, we report a case of a 56-year-old female patient with c- ANCA-associated vasculitis. The patient presented with a localized skin thickening on the medial aspect of the left thigh and an oral ulcer. Skin biopsy shows erythema induratum (nodular vasculitis). After several investigations, we found c-ANCA positive and concluded the diagnosis as c-ANCA-associated vasculitis. We treat the patient with injectable methylprednisolone, injectable cyclophosphamide, and Mesna. Then we gave oral mycophenolate mofetil and prednisolone.

J Dhaka Med Coll. 2022; 31(1) : 158-162

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Published

2023-05-03

How to Cite

Khan, M. A. A. ., Miah, M. T. ., Haque, S. N. ., Naafi, S. M. U., & Abrar, S. . (2023). A Case of C-ANCA Associated Vasculitis Presenting With Localised Skin Thickening. Journal of Dhaka Medical College, 31(1), 158–162. https://doi.org/10.3329/jdmc.v31i1.65490

Issue

Section

Case Reports