High Sensitive C-Reactive Protein (hs-CRP) and Its Correlation with Angiographic Severity of Patient with Coronary Artery Disease (CAD)

Abstract

Background: Association between the plasma hs-CRP levels and the severity of coronary stenosis in subjects remains controversial. This cross sectional study was performed in the Department of Cardiology, Dhaka Medical College during July 2008 to December 2009, to determine whether the concentrations of hs-CRP correlate with the coronary atherosclerotic disease assessed by coronary angiography.

Methods: For this purpose, a total number of 90 consecutive patients having IHD admitted in the Dhaka Medical College Hospitals were enrolled in this study. Patients were divided into three groups according to their level of hs-CRP. Out of 90 cases, 22(24.4%) patients were in group I, in group II 33(36.7%) patients and rest 35(38.9%) were in group III according to their hs-CRP level. Severity of CAD was assessed by vessel score, stenosis score and extent score.

Result: Significant positive correlation (r=0.7409; p<0.001 r=0.6648; p<0.001 and r=0.6386; p<0.001) was found between hs-CRP and vessel score, stenosis score and hs-CRP and extent score suggesting increasing level of hs-CRP strongly suggestive of extensive coronary artery disease.

Conclusion: High level of hs-CRP strongly suggestive of extensive coronary artery disease

Key words: hs-CRP; angiogram; coronary artery disease; vessel score; stenosis score and extent score.

DOI: 10.3329/jdmc.v19i2.7076

J Dhaka Med Coll. 2010; 19(2) : 91-97