Association Between Serum C-Reactive Protein (CRP) And D-Dimer Levels In Covid-19 Patients In A Tertiary Level Hospital, Khulna

Authors

  • Tasnim Rahman Associate Professor, Department of Pathology, Gazi Medical College, Khulna, Bangladesh.
  • Nursarat Ahmed Associate Professor and Head, Department of Microbiology, Gazi Medical College, Khulna, Bangladesh.
  • Baishakhi Islam Associate Professor and Head, Department of Pharmacology & Therapeutics, Gazi Medical College, Khulna, Bangladesh.
  • Mohammad Monzurul Alam Bhuiyan Assistant Professor, Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University, Bangladesh.
  • Abu Md Mayeenuddin Al Amin Associate Professor, Department of Microbiology, Gazi Medical College, Khulna, Bangladesh.
  • Arifa Begum Associate Professor, Department of Physiology, Gazi Medical College, Khulna, Bangladesh.
  • Abdullah Al Faroque Associate Professor and Head, Department of Pathology, Gazi Medical College, Khulna, Bangladesh.
  • Prithwy Shankar Biswas Associate Professor, Department of Biochemistry, Gazi Medical College, Khulna, Bangladesh.
  • Srabonti Ghosh Lecturer, Department of Microbiology, Khulna Medical College, Khulna, Bangladesh.

DOI:

https://doi.org/10.3329/jdmc.v32i1.76448

Keywords:

COVID-19, CRP, D-dimer

Abstract

Background: The novel corona virus disease 2019 (COVID-19) is major public health issue. It is the most significant global health challenge in the world. Biomarkers play a significant role to detect the severity of COVID-19 infection in the perspective of management of the patients.

 Aim and objective: We aimed to assess the association between the levels of C-Reactive Protein and D-dimer in COVID-19 patients.

Methods: This cross-sectional study was conducted in the department of Pathology and department of Microbiology GMCH, Khulna. 152 patients with SARS-CoV-2 (COVID -19) positive patients were enrolled in this study. C-reactive protein and D-dimer levels are measured in the laboratory of Pathology department, GMCH, Khulna. All statistical computations were performed by using window-based computer software devised with Statistical Packages for Social Sciences (IBM SPSS Statistics 21 version).

Results: In this study CRP level was found of mean value of 62.84± 44.64 mg/L with a range of 1.40-195.20 mg/L. It was normal in 21 (13.8%) patients and increased in in 131 patients (86.2 %). The mean value of D-dimer was 2.48 ± 02.20 mg/L with a range of 0.10-9.35 mg/L. D-dimer was normal in 26 (17.1%) patients, whereas it was increased in 126 patients (82.9 %). We performed Pearson’s correlation-coefficient (r) test to compare the association between the levels of CRP with D-dimer in COVID-19 positive patients. There was moderately positive and significant correlation (r = +0.647, p <0.05) between the levels of CRP and D-dimer.

Conclusion: There was statistically significant correlation between the levels of serum CRP with D-dimer in COVID-19 positive patients. These two biomarkers can be used to assess the severity in patients with COVID-19 positive with thrombotic disorder for reduction of morbidity and mortality of COVID positive patients.

J Dhaka Med Coll. 2023; 32(1) : 57-62

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Published

2024-10-27

How to Cite

Rahman, T., Ahmed, N., Islam, B., Bhuiyan, M. M. A., Al Amin, A. M. M., Begum, A., Faroque, A. A., Biswas, P. S., & Ghosh, S. (2024). Association Between Serum C-Reactive Protein (CRP) And D-Dimer Levels In Covid-19 Patients In A Tertiary Level Hospital, Khulna. Journal of Dhaka Medical College, 32(1), 57–62. https://doi.org/10.3329/jdmc.v32i1.76448

Issue

Vol. 32 No. 1 (2023)

Section

Original Articles