Outcome Of Induction Of Labour By Intravaginal Prostaglandin Versus Intravenous Oxytocin In a Tertiary Care Hospital

Abstract

Aim of the study was to determine the effectiveness and safety of intravaginal misoprostol VS intravenous oxytocin in induction of labour and to compare the induction delivery interval between prostaglandin induction and oxytocin induction and to detect maternal and foetal outcome between prostaglandin induction and oxytocin induction and also reduce the rate of caesarean section .

A prospective, randomized trial was carried out in one hundred singleton pregnant women admitted in Dhaka National Medical Hospital during the period of January 2006 to December 2006.

Women who had unfavorable cervix (Bishops score<) were selected. 50 of them received 50 mgm misoprostol intravaginally for three doses, 6 hourly. Another 50 patient received intravenous starting from 10 mU /ml up to 40mU.Thirty-nine patients out of 50 patients of misoprostol group achieved normal vaginal delivery. Rest eleven patients ended by caesarean section. 82% of this group delivered within 10 hours. The maximum required dose was 50-150mgm.

Maternal complications were PPH 2%. Neonatal outcome were satisfactory. Thirty six patients out of 50 patients of Oxytocin group achieved normal vaginal delivery. Rest fourteen patients ended by caesarean section. Only 66% of this group delivered within 10 hours. The maximum required dose was 40mU/ml.

From the study it was found that intravaginal misoprostol is well tolerated and very effect then intravenous oxytocin in induction of labour in unfavorable cervix. It certainly reduces the number of caesarean section. It is cost effective.

DOI: http://dx.doi.org/10.3329/jdnmch.v17i2.12213

J. Dhaka National Med. Coll. Hos. 2011; 17 (02): 30-33