Use of Combination of Mifepristone and Misoprostol to Terminate Early Pregnancy: Experience at a Tertiary Care Teaching Hospital

Abstract

Background: Termination of pregnancy is well prescribed method all over the world to terminate the early pregnancy with the combination of mifepristone and misoprostol tablet orally.

Objective: The purpose of this present study was to determine the efficacy of mifipristone (200 mg) for medical termination of early pregnancy with oral misoprostol 800 mcg 24 hours later.

Methodology: This observational study was done in the Department of Gynaecology & Obstetrics at Shaheed Suhrawardy Medical College & Hospital, Dhaka, Bangladesh among outdoor patients in 6 months period from July 2014 to December 2014. The patients with intrauterine pregnancy up to 9 weeks and blighted ovum were included. Incomplete abortion and extrauterine pregnancy were excluded. Mifepristone 200 mg followed by misoprostol 800 mg after 24 hours had been given.

Result: Total 50 patients with 9 weeks of pregnancy were selected over the period of 6 months requesting termination of pregnancy. This study showed termination of early pregnancy up to 9 weeks with tablet mifepristone and tablet misoprostole which was effective as well as the expulsion rate of the product of conception was 92.0% cases and among them 32.0% patients were needed extended dose of misoprostol and 8.0% cases had incomplete abortion who needed surgical evacuation. Some patients had some complications like vomiting, fever, abdominal pain and excessive per vaginal bleeding which were managed accordingly.

Conclusion: Mifepristone 200 mg followed by misoprostol 800 mcg orally is an effective method for termination early pregnancy with minimum side effects.

Journal of Science Foundation 2017;15(1):9-13