Effects of Omega-3 Fatty Acid Supplementation on Serum Alanine Transferase and Aspartate Transferase Levels in Middle Aged Patients with Type 2 Diabetes Mellitus

Abstract

Background: People with type2 diabetes mellitus (DM) are at amplified chance of non-alcoholic fatty liver disease.

Objective: The purpose of the present study was to observe the effects of omega-3 fatty acid supplementation alanine transferase (ALT) and aspartate transferase (AST) in middle age patients with type 2 DM.

Methodology: A prospective interventional study in  2017 had been recruited 52  type 2 diabetic patients of both sexes aged 40 to 50 years. Among them, 27 patients were given fish oil capsule orally ( omega 3 fatty acid 2g/day) for  consecutive 12 weeks and  r 25  patients without supplementation w and ere selected as control  also studied after 12 weeks serum serum ALT and AST of all patients was estimated by enzymatic colorimetric method at baseline and after 12 weeks For statistical analysis,

Results: In this study ALT and AST significantly decreased in patients supplemented with omega-3 fatty acid after 12 weeks, ALT (alanine aminotransferase) and AST (aspartate transaminase) were decreased in diabetic patients after supplementation with omega-3 fatty acid in comparison to control group.

Conclusion: It can be concluded that omega-3 fatty acid supplementation was effective to reduce ALT and AST levels in diabetic patients and it may be helpful to minimize the risk of fatty liver in type-2 DM.

Journal of Science Foundation, July 2020;18(2):62-66