Anti Epileptic Activity of Poly Herbal Extract from Indian Medicinal Plants

Authors

  • Gunasekaran Balamurugan C. L. Baid Metha College of Pharmacy
  • Murali Dharan C. L. Baid Metha College of Pharmacy
  • Selva Rajan Captain Srinivasa Murthi Drug Research Institute for Ayurveda

DOI:

https://doi.org/10.3329/jsr.v1i1.1057

Keywords:

Anti epileptic activity, Biogenic amines, Maximal Electro Shock, Poly herbal extract, Seizures.

Abstract

With the introduction of allopathic drugs, the use of crude drugs from medicinal plants is on the decline and subsequently this traditional knowledge may be lost in the near future. In the present study, a poly herbal extract comprising of Withania somnifera Dunal, a medicinal plant used in many neuro protective Ayurvedic preparations along with five other medicinal plants were evaluated for its protective effect against seizures induced by Maximal Electro shock (MES) method in rats. A daily dose of 250 and 500 mg/kg of the extract was administered to the animals for 15 days, after which seizures were induced by Maximum electro shock method and the duration of various phases of epileptic attacks were recorded and compared with the control animals. A significant (P < 0.01 and P < 0.001) reduction in the time taken for righting reflex (recovery) was noted in the experimental animals. The levels of biogenic amines such as dopamine, serotonin and nor-adrenaline in the forebrain region were also estimated and a significant level of restoration was observed in the extract treated animals. Significant results were observed in the estimated parameters thereby justifying the use of these medicinal plants in the treatment of epilepsy.

 

Keywords: Anti epileptic activity; Biogenic amines; Maximal Electro Shock; Poly herbal extract; Seizures.

 

©2009 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

 

DOI: 10.3329/jsr.v1i1.1057

 

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Author Biographies

Gunasekaran Balamurugan, C. L. Baid Metha College of Pharmacy

G. Balamurugan
Research Scholar
Department of Pharmacology and Toxicology
C. L. Baid Metha College of Pharmacy
Thoraipakkam,
Chennai - 600 097
Tamil Nadu, INDIA

Murali Dharan, C. L. Baid Metha College of Pharmacy

Professor and Head
Department of Pharmacology and Toxicology
C. L. Baid Metha College of Pharmacy
Thoraipakkam,
Chennai - 600 097
Tamil Nadu, INDIA

Selva Rajan, Captain Srinivasa Murthi Drug Research Institute for Ayurveda

Dr. Selva Rajan
Research Officer,
Captain Srinivasa Murthi Drug Research Institute for Ayurveda
Central Council for Research in Ayurveda and Siddha,
Arumbakkam, Chennai-600 106
Tamil Nadu, India.

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Published

2008-12-24

How to Cite

Balamurugan, G., Dharan, M., & Rajan, S. (2008). Anti Epileptic Activity of Poly Herbal Extract from Indian Medicinal Plants. Journal of Scientific Research, 1(1), 153–159. https://doi.org/10.3329/jsr.v1i1.1057

Issue

Section

Section B: Chemical and Biological Sciences