Inhibitory Effects of <i>Nigella sativa</i> Seed Extract on Adrenaline-Induced Dyslipidemia and Left Ventricular Hypertrophy in Rats

Authors

  • Y. Ali Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh
  • M. S. Islam Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh
  • A. H. M. K. Alam Associate Professor, Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh
  • M. A. A. Rahman University of Rajshahi
  • Al Mamun University of Rajshahi
  • M. K. Hossain University of Rajshahi
  • A. K. M. M. Hossain University of Rajshahi
  • M. S. Parvin University of Rajshahi
  • M. Rashid Rajshahi University

DOI:

https://doi.org/10.3329/jsr.v5i2.12203

Keywords:

Adrenaline, Dyslipidemia, LVH, NSSE, Atorvastatin.

Abstract

The aim of this study was to investigate the inhibitory effect of Nigella sativa seed extract (abbreviated as NSSE) on adrenaline-induced dyslipidemia and left ventricular hypertrophy (LVH) in rats. Intraperitoneal injection of adrenaline for two weeks induced dyslipidemia whereas injection of adrenaline for four weeks induced both dyslipidemia and LVH significantly, compared with normal rats. Injection of NSSE with different doses (0.5, 1 and 1.5 mg/kg body weight, BW) on adrenaline-induced dyslipidemic rats (AIDRs) for two weeks significantly reduced TC, TG and LDL-C and increased HDL-C compared with AIDRs and the most effective dose was 1.5 mg/kg BW. Treatment with NSSE (1.5 mg/kg BW) on AIDRs for eight weeks, significant anti-dyslipidemic effect was observed. Moreover, NSSE significantly increased free radical scavenging activity and attenuated the LVH and cardiomyocyte size compared with AIDRs. The results suggested that the anti-dyslipidemic, antioxidative and inhibitory effects of NSSE on LVH were closely resembled to that of atorvastatin, a most effective lipid lowering agent. Therefore, NSSE might be used as a therapeutic alternative or as a combination with drug in the treatment of dyslipidemia and LVH.

Keywords: Adrenaline; Dyslipidemia; LVH; NSSE; Atorvastatin.

© 2013 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

doi: http://dx.doi.org/10.3329/jsr.v5i2.12203        J. Sci. Res. 5 (2), 325-334 (2013)

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Author Biographies

M. A. A. Rahman, University of Rajshahi

Associate Professor, Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh

Al Mamun, University of Rajshahi

Lecturer, Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh

M. K. Hossain, University of Rajshahi

Department of Biochemistry and Molecular Biology, University of Rajshahi,  Bangladesh

A. K. M. M. Hossain, University of Rajshahi

Associate Professor, Department of Pharmacy

M. S. Parvin, University of Rajshahi

Associate Professor, Department of Pharmacy

M. Rashid, Rajshahi University

Professor and Chairman, Pharmacy Department,Pharmacology, Molecular Biology

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Published

2013-04-22

How to Cite

Ali, Y., Islam, M. S., Alam, A. H. M. K., Rahman, M. A. A., Mamun, A., Hossain, M. K., Hossain, A. K. M. M., Parvin, M. S., & Rashid, M. (2013). Inhibitory Effects of <i>Nigella sativa</i> Seed Extract on Adrenaline-Induced Dyslipidemia and Left Ventricular Hypertrophy in Rats. Journal of Scientific Research, 5(2), 325–334. https://doi.org/10.3329/jsr.v5i2.12203

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Section

Section B: Chemical and Biological Sciences