Preventive Effect of Ganoderma lucidum on Paracetamol-induced Acute Hepatotoxicity in Rats

Authors

  • M. M. Rahman Jahangirnagar University, Savar
  • S. Hossain Jahangirnagar University

DOI:

https://doi.org/10.3329/jsr.v5i3.14055

Abstract

The effect of Ganoderma lucidum in paracetamol-induced acute hepatotoxicity was investigated on Wistar rats in the present study. Hepatotoxicity was induced by oral administration of paracetamol (500 mg/kg of body weight) for 7 consecutive days. The extent of liver damage was studied by assessing biochemical parameters comprising of plasma aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH), total bilirubin (TB) and total plasma total protein (TP). Oral administration of paracetamol significantly increased the plasma levels of AST, ALT, ALP and LDH with concomitant decrease of TP. The feeding of G. lucidum (1% powder with basal food) significantly reversed the plasma levels of ALT, AST, ALP, LDH, and TP nearly to those of the normal rats. Thus, the results of the present demonstrate that the G. lucidum has significant hepatoprotective activity against paracetamol induced acute hepatotoxicity in rats.

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Author Biographies

M. M. Rahman, Jahangirnagar University, Savar

Biochemisrty and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342

S. Hossain, Jahangirnagar University

Professor,Biochemisrty and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342

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Published

2013-08-29

How to Cite

Rahman, M. M., & Hossain, S. (2013). Preventive Effect of Ganoderma lucidum on Paracetamol-induced Acute Hepatotoxicity in Rats. Journal of Scientific Research, 5(3), 573–578. https://doi.org/10.3329/jsr.v5i3.14055

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Section

Section B: Chemical and Biological Sciences