Relationship Between High Sensitivity C-reactive Protein and CagA Positive <i>Helicobacter pylori</i> in Cardiac Syndrome X

Authors

  • Y. Rasmi Faculty of Medicine, Urmia Medical Sciences University
  • M. H. Seyed-Mohammadzad
  • S. Raeisi

DOI:

https://doi.org/10.3329/jsr.v5i3.14171

Keywords:

Cardiac syndrome X, Helicobacter pylori, Inflammation, hs-CRP, Cytotoxin-associated gene A.

Abstract

Cytotoxin-associated gene A (CagA) may induce a persistent systemic inflammatory response in cardiac syndrome X (CSX). We aimed to evaluate relationship of CagA status and high sensitivity C-reactive protein (hs-CRP) in CSX patients. Sixty CSX patients and 60 gender matched controls were enrolled. Plasma samples were tested in terms of the presence of IgG antibody to Helicobacterpylori (anti-H. pylori) and CagA (anti-CagA) using ELISA method. Also, plasma level of hs-CRP was measured by ELISA method. CSX patients were detected to have significantly higher plasma hs-CRP level in comparison with the control ones (3.64 ± 3.07 vs. 0.54 ± 0.49, µg/ml, P = 0.0001). Plasma levels of hs-CRP in CSX patients with anti-CagA+ were significantly higher than those in anti-CagA(-) (CSX: 4.66±3.63 vs. 2.58±1.95 µg/ml, P = 0.011). Also, plasma levels of hs-CRP in the controls with anti-CagA+ were significantly higher than those in anti-CagA- (1.05±0.68 vs. 0.32±0.31 µg/ml, respectively, P = 0.004). The present data suggested that CagA status was probably associated with susceptibility to severe CSX by causing inflammation. The evidence for this hypothesis indicated that levels of hs-CRP increased in anti-CagA+ patients compared to the anti-CagA- ones.


Keywords: Cardiac syndrome X; Helicobacter pylori; Inflammation ; hs-CRP, Cytotoxin-associated gene A.

© 2013 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

doi: http://dx.doi.org/10.3329/jsr.v5i3.14171 J. Sci. Res. 5 (3), 527-533 (2013)

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Author Biography

Y. Rasmi, Faculty of Medicine, Urmia Medical Sciences University

Dept of Clinical Biochemistry

Faculty of Medicine

Urmia Medical Sciences University

Urmia, Iran

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Published

2013-08-29

How to Cite

Rasmi, Y., Seyed-Mohammadzad, M. H., & Raeisi, S. (2013). Relationship Between High Sensitivity C-reactive Protein and CagA Positive <i>Helicobacter pylori</i> in Cardiac Syndrome X. Journal of Scientific Research, 5(3), 527–533. https://doi.org/10.3329/jsr.v5i3.14171

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Section

Section B: Chemical and Biological Sciences