Comparative Antimicrobial Activities of some Monosaccharide and Disaccharide Acetates

Authors

  • M. M. Matin University of Chittagong
  • M. M. H. Bhuiyan
  • A. Afrin
  • D. C. Debnath

DOI:

https://doi.org/10.3329/jsr.v5i3.15695

Keywords:

Glucofuranose, Glucopyranose, Acetylation, Antimicrobial activity, Structure activity relationship (SAR).

Abstract

A number of furanose (2,4) and pyranose (5,7,9,11,13) acetates were prepared by direct acetylation method. For comparative antimicrobial studies sucrose octaacetate (14) was also prepared. All the compounds (1-14) were screened for in vitro antibacterial activity against ten human pathogenic bacteria viz. Bacillus subtilis, Bacillus cereus, Bacillus megaterium, Staphylococcus aureus, Escherichia coli, INABA ET (Vibrio), Pseudomonas species, Salmonella paratyphi, Salmonella typhi and Shigella dysenteriae. These compounds were also screened for in vitro antifungal activity against four pathogenic fungi viz. Aspergillus niger, Alternaria alternata, Curvularia lunata and Fusarium equiseti. The study revealed that the pyranose acetate derivatives (5,7,9,11,13) are more prone towards antimicrobial functionality than those of the furanose acetates (2,4) and sucrose octaacetate (14).

 

Keywords: Glucofuranose; Glucopyranose; Acetylation; Antimicrobial activity; Structure activity relationship (SAR).

 

© 2013 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

 

doi: http://dx.doi.org/10.3329/jsr.v5i3.15695 J. Sci. Res. 5 (3), 515-525 (2013)

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Author Biographies

M. M. Matin, University of Chittagong

Professor

Department of Chemistry

University of Chittagong

Chittagong 4331

M. M. H. Bhuiyan

M. M. H. Bhuiyan

Organic Research Laboratory, Department of Chemistry, University of Chittagong, Chittagong-4331

A. Afrin

A. Afrin

Department of Applied & Environmental Chemistry, University of Chittagong, Chittagong-4331

D. C. Debnath

D. C. Debnath

Organic Research Laboratory, Department of Chemistry, University of Chittagong, Chittagong-4331

2Department of Applied & Environmental Chemistry, University of Chittagong,

Chittagong-4331, Bangladesh.

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Published

2013-08-29

How to Cite

Matin, M. M., Bhuiyan, M. M. H., Afrin, A., & Debnath, D. C. (2013). Comparative Antimicrobial Activities of some Monosaccharide and Disaccharide Acetates. Journal of Scientific Research, 5(3), 515–525. https://doi.org/10.3329/jsr.v5i3.15695

Issue

Section

Section B: Chemical and Biological Sciences