Cytotoxic Studies on Two Meliaceae plants: Chukrasia Tabularis and Aglaia Roxburghiana

Authors

  • M. K. Islam Phytochemical Research Laboratory, Faculty of Pharmacy, University of Dhaka
  • I. Z. Eti Phytochemical Research Laboratory, Faculty of Pharmacy, University of Dhaka
  • J. A. Chowdhury University of Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/jsr.v1i2.1645

Keywords:

Chukrasia tabularis, Aglaia roxburghiana, Meliacea, Cytotoxicity.

Abstract

The paper details a biological investigation on chukrasia tabularis and aglaia roxburghiana, species of meliaceae. The methanol crude extract of chukrasia tabularis and aglaia roxburghiana have been screened for antitumor potentials using brine shrimp lethality bioassay with ten different concentrations. An established cytotoxic agent vincristine sulphate has been used to compare the results. From the graphs the concentration of methanolic crude extract yields the value of LC50 (50% mortality) as 1.58mg/ml and 2.21mg/ml for chukrasia tabularis and aglaia roxburghiana, respectively. In the same way the concentration at which 90% mortality (LC90) occurs for the methanol extract are obtained from the graphs and the values have been found to be 141.41mg/ml and 70.70mg/ml for chukrasia tabularis and aglaia roxburghiana, respectively.

Keywords: Chukrasia tabularis; Aglaia roxburghiana; Meliacea; Cytotoxicity.

 

© 2009 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

 

DOI: 10.3329/jsr.v1i2.1645

 

 

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Author Biographies

M. K. Islam, Phytochemical Research Laboratory, Faculty of Pharmacy, University of Dhaka

 

Phytochemical Research Laboratory, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh

I. Z. Eti, Phytochemical Research Laboratory, Faculty of Pharmacy, University of Dhaka

Phytochemical Research Laboratory, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh

J. A. Chowdhury, University of Dhaka, Bangladesh

Lecturer

Department of Pharmaceutical Technology

Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh

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Published

2009-04-23

How to Cite

Islam, M. K., Eti, I. Z., & Chowdhury, J. A. (2009). Cytotoxic Studies on Two Meliaceae plants: Chukrasia Tabularis and Aglaia Roxburghiana. Journal of Scientific Research, 1(2), 399–402. https://doi.org/10.3329/jsr.v1i2.1645

Issue

Vol. 1 No. 2 (2009)

Section

Section B: Chemical and Biological Sciences

License

© Journal of Scientific Research

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